About Cytochrome P450 2D6
Cytochrome P450 2D6 (CYP2D6) is a protein
from Homo sapiens identified by UniProt accession
P10635, 497 residues long.
MolForge cross-references it against 0 known binders and
412 disease associations.
Target properties
| Protein name | Cytochrome P450 2D6 |
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| UniProt accession | P10635 |
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| Gene | CYP2D6 |
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| Organism | Homo sapiens |
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| Length | 497 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (412)
Diseases linked to this target (Open Targets).
- response to tramadol · score 0.55
- debrisoquine, poor metabolism of · score 0.49
- schizophrenia · score 0.25
- cutaneous melanoma · score 0.25
- unipolar depression · score 0.23
- glioblastoma multiforme · score 0.23
- testosterone measurement · score 0.23
- response to selective serotonin reuptake inhibitor · score 0.21
- intelligence · score 0.21
- urinary metabolite measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10635-F1 | alphafold | PREDICTED | 94.42 | — |
Amino-acid sequence (497 residues)
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLRIVVA DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVSPSPY ELCAVPR
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