Nociceptin receptor (OPRL1)

About Nociceptin receptor

Nociceptin receptor (OPRL1) is a protein from Homo sapiens identified by UniProt accession P41146, 370 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	Nociceptin receptor
UniProt accession	P41146
Gene	OPRL1
Organism	Homo sapiens
Length	370 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (158)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
triglyceride measurement · score 0.31
BMI-adjusted waist-hip ratio · score 0.30
pain · score 0.28
BMI-adjusted waist circumference · score 0.27
testosterone measurement · score 0.27
high density lipoprotein cholesterol measurement · score 0.27
mean corpuscular volume · score 0.26
glioblastoma multiforme · score 0.26
cardiovascular disease · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41146-F1	alphafold	PREDICTED	82.30	—

Amino-acid sequence (370 residues)

MEPLFPAPFW EVIYGSHLQG NLSLLSPNHS LLPPHLLLNA SHGAFLPLGL KVTIVGLYLA VCVGGLLGNC LVMYVILRHT KMKTATNIYI FNLALADTLV LLTLPFQGTD ILLGFWPFGN ALCKTVIAID YYNMFTSTFT LTAMSVDRYV AICHPIRALD VRTSSKAQAV NVAIWALASV VGVPVAIMGS AQVEDEEIEC LVEIPTPQDY WGPVFAICIF LFSFIVPVLV ISVCYSLMIR RLRGVRLLSG SREKDRNLRR ITRLVLVVVA VFVGCWTPVQ VFVLAQGLGV QPSSETAVAI LRFCTALGYV NSCLNPILYA FLDENFKACF RKFCCASALR RDVQVSDRVR SIAKDVALAC KTSETVPRPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards