About Broad substrate specificity ATP-binding cassette transporter ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) is a protein
from Homo sapiens identified by UniProt accession
Q9UNQ0, 655 residues long.
MolForge cross-references it against 0 known binders and
863 disease associations.
Target properties
| Protein name | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
|---|
| UniProt accession | Q9UNQ0 |
|---|
| Gene | ABCG2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 655 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (863)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.72
- gout · score 0.69
- uric acid measurement · score 0.55
- body mass index · score 0.50
- serum metabolite measurement · score 0.47
- coffee consumption measurement · score 0.47
- neuroimaging measurement · score 0.46
- drug use measurement · score 0.46
- urolithiasis · score 0.46
- HbA1c measurement · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNQ0-F1 | alphafold | PREDICTED | 85.22 | — |
Amino-acid sequence (655 residues)
MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS GFLPCRKPVE KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS GLSGDVLING APRPANFKCN SGYVVQDDVV MGTLTVRENL QFSAALRLAT TMTNHEKNER INRVIQELGL DKVADSKVGT QFIRGVSGGE RKRTSIGMEL ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF SIHQPRYSIF KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH QLSGGEKKKK ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII VTVVLGLVIG AIYFGLKNDS TGIQNRAGVL FFLTTNQCFS SVSAVELFVV EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP MRMLPSIIFT CIVYFMLGLK PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL MTICFVFMMI FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF LKKYS
Explore Broad substrate specificity ATP-binding cassette transporter ABCG2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets