Fusidic acid

DERMATOLOGICALS

Key facts

Fusidic acid is a drug catalogued in DrugCentral. DrugCentral lists 3 molecular targets, including ABCB11, Abcb11 and ABCG2. Recorded indications include Acne vulgaris, Actinomycotic infection, Acute bacterial sinusitis and Acute gonococcal cervicitis.

• Molecular targets: ABCB11, Abcb11 and ABCG2 (3 listed in DrugCentral).
• Indications: Acne vulgaris, Actinomycotic infection, Acute bacterial sinusitis, Acute gonococcal cervicitis and Acute gonococcal endometritis and others.
• ATC code: D06AX01 (Other antibiotics for topical use).
• Molecular formula: C31H48O6; molecular weight 516.72 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (100)

• Acne vulgaris
• Actinomycotic infection
• Acute bacterial sinusitis
• Acute gonococcal cervicitis
• Acute gonococcal endometritis
• Acute gonococcal epididymo-orchitis
• Acute gonococcal urethritis
• Allergic conjunctivitis
• Anterior uveitis
• Anthrax
• Bacterial conjunctivitis
• Bacterial infection due to Klebsiella pneumoniae
• Bacterial infection due to Serratia
• Bacterial infection of skin
• Bacterial keratitis
• Bacterial meningitis
• Bacterial peritonitis
• Bacterial pneumonia
• Bacterial septicemia
• Bacterial urinary infection
• Bartonellosis
• Blepharoconjunctivitis
• Boutonneuse fever
• Brill-Zinsser disease
• Bronchitis
• Brucellosis
• Burn Wound Infections
• Chancroid
• Chlamydia trachomatis infection of genital structure
• Chlamydial infection
• + 70 more

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Bile salt export pump	ABCB11	unknown	IC50 4.94
Bile salt export pump	Abcb11	unknown	IC50 4.76
ATP-binding cassette sub-family G member 2	ABCG2	unknown	IC50 4.28

ATC classification

ATC code	Therapeutic hierarchy
D06AX01	DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › ANTIBIOTICS FOR TOPICAL USE › Other antibiotics for topical use
D09AA02	DERMATOLOGICALS › MEDICATED DRESSINGS › MEDICATED DRESSINGS › Medicated dressings with antiinfectives
J01XC01	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Steroid antibacterials
S01AA13	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Rhabdomyolysis	268.0
Monocytosis	120.5
Ulcerative keratitis	96.9
Exposure to SARS-CoV-2	92.5
Drug interaction	78.4
Eye inflammation	76.8
Stevens-Johnson syndrome	68.8
Labelled drug-drug interaction medication error	62.5
SARS-CoV-2 test positive	60.4
Biliary sepsis	50.3
Eczema herpeticum	47.6
Mechanical ventilation	46.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Fusidic acid is on its molecule page.

• Molecular formula: C₃₁H₄₈O₆
• Molecular weight: 516.72 g/mol
• CAS number: 6990-06-3
• InChIKey: IECPWNUMDGFDKC-MZJAQBGESA-N
• PubChem CID: 3000226

C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]1(C)[C@H]2[C@H](O)C[C@H]2\C([C@H](C[C@]12C)OC(C)=O)=C(/CCC=C(C)C)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Fusidic acid used for?

DrugCentral lists the following indications for Fusidic acid: Acne vulgaris, Actinomycotic infection, Acute bacterial sinusitis, Acute gonococcal cervicitis, Acute gonococcal endometritis, Acute gonococcal epididymo-orchitis, Acute gonococcal urethritis and Allergic conjunctivitis and others.

How does Fusidic acid work?

Its molecular targets in DrugCentral include ABCB11, Abcb11 and ABCG2.

What is the chemical formula of Fusidic acid?

Fusidic acid has the molecular formula C31H48O6 and a molecular weight of 516.72 g/mol.

Sources

• DrugCentral drug card 1261 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1256987 — compound record and bioactivity
• PubChem CID 3000226 — chemical identifiers
• DrugBank DB02703 — drug record
• FDA UNII 59XE10C19C — substance identity
• UniProt O95342 (ABCB11) — target protein
• UniProt Q9UNQ0 (ABCG2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.