Reserpine

Catecholamine-depleting Sympatholytic — CARDIOVASCULAR SYSTEM

Key facts

Reserpine is an ofm drug in the Catecholamine-depleting Sympatholytic class catalogued in DrugCentral. It was first approved by the FDA in 1955. DrugCentral lists 16 molecular targets, including SLC18A2, Slc18a2 and SLC18A2. Recorded indications include Hypertensive disorder and Psychotic disorder.

• Approval status: ofm (first approved 1955 by the FDA).
• Drug class: Catecholamine-depleting Sympatholytic.
• Molecular targets: SLC18A2, Slc18a2, SLC18A2 and SLC18A1 (16 listed in DrugCentral).
• Indications: Hypertensive disorder and Psychotic disorder.
• ATC code: C02AA02 (Rauwolfia alkaloids).
• Molecular formula: C33H40N2O9; molecular weight 608.69 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Hypertensive disorder
• Psychotic disorder

Contraindications (48)

• Acute nephropathy
• Acute pancreatitis
• Anuria
• Azotemia
• Benign intracranial hypertension
• Calculus in biliary tract
• Cerebrovascular accident
• Chronic disease of respiratory system
• Chronic heart failure
• Cirrhosis of liver
• Conduction disorder of the heart
• Dehydration
• Depressive disorder
• Diabetes mellitus
• Diabetes mellitus type 1
• Diabetes mellitus type 2
• Disease of liver
• Disorder of coronary artery
• Electroconvulsive therapy
• Epilepsy
• Fluid volume disorder
• Gout
• Hepatic coma
• Hepatic failure
• Hypercalcemia
• Hypercholesterolemia
• Hyperparathyroidism
• Hypertriglyceridemia
• Hyperuricemia
• Hypochloremic alkalosis
• + 18 more

Mechanism & targets

• Established pharmacologic class: Catecholamine-depleting Sympatholytic

Molecular targets (16)

Target	Gene	Action	Activity
Synaptic vesicular amine transporter	SLC18A2	unknown	Ki 9.00
Synaptic vesicular amine transporter	Slc18a2	unknown	IC50 8.75
Synaptic vesicular amine transporter	SLC18A2	inhibitor	Ki 7.90
Chromaffin granule amine transporter	SLC18A1	inhibitor	Ki 7.45
Multidrug resistance protein 1	ABCB1	unknown	Ki 7.00
D(2) dopamine receptor	DRD2	unknown	Ki 6.23
D(3) dopamine receptor	DRD3	unknown	Ki 6.22
Sodium-dependent serotonin transporter	SLC6A4	unknown	Kd 5.84
Sodium channel alpha subunits; brain (Types I, II, III)	SCN1A|SCN2A|SCN3A	unknown	IC50 5.80
Mu-type opioid receptor	OPRM1	unknown	Ki 5.77
Acetylcholinesterase	ACHE	unknown	IC50 5.77
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 5.74
Cholinesterase	BCHE	unknown	IC50 5.55
D(1A) dopamine receptor	DRD1	unknown	Ki 5.42
Quinolone resistance protein NorA	norA	unknown	IC50 5.15
ATP-binding cassette sub-family G member 2	ABCG2	unknown	IC50 4.58

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1955-10-12	FDA	—	LANNETT

ATC classification

ATC code	Therapeutic hierarchy
C02AA02	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, CENTRALLY ACTING › Rauwolfia alkaloids
C02AA52	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, CENTRALLY ACTING › Rauwolfia alkaloids
C02LA01	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Rauwolfia alkaloids and diuretics in combination
C02LA51	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Rauwolfia alkaloids and diuretics in combination
C02LA71	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Rauwolfia alkaloids and diuretics in combination

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Reserpine is on its molecule page.

• Molecular formula: C₃₃H₄₀N₂O₉
• Molecular weight: 608.69 g/mol
• CAS number: —
• InChIKey: QEVHRUUCFGRFIF-MDEJGZGSSA-N
• PubChem CID: 5770

CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=C4C=CC(OC)=C5)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Reserpine used for?

DrugCentral lists the following indications for Reserpine: Hypertensive disorder and Psychotic disorder.

How does Reserpine work?

Its molecular targets in DrugCentral include SLC18A2, Slc18a2, SLC18A2 (inhibitor) and SLC18A1 (inhibitor).

When was Reserpine first approved?

Reserpine was first approved by the FDA in 1955.

What drug class does Reserpine belong to?

Reserpine is in the Catecholamine-depleting Sympatholytic class.

What is the chemical formula of Reserpine?

Reserpine has the molecular formula C33H40N2O9 and a molecular weight of 608.69 g/mol.

Sources

• DrugCentral drug card 2370 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL772 — compound record and bioactivity
• PubChem CID 5770 — chemical identifiers
• DrugBank DB00206 — drug record
• FDA UNII 8B1QWR724A — substance identity
• DailyMed: FDA labels for Reserpine — current prescribing information (label search)
• UniProt Q05940 (SLC18A2) — target protein
• UniProt P54219 (SLC18A1) — target protein
• UniProt P08183 (ABCB1) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P31645 (SLC6A4) — target protein

How this page is built: methodology · editorial policy & corrections.