About Chromaffin granule amine transporter
Chromaffin granule amine transporter (SLC18A1) is a protein
from Homo sapiens identified by UniProt accession
P54219, 525 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Chromaffin granule amine transporter |
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| UniProt accession | P54219 |
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| Gene | SLC18A1 |
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| Organism | Homo sapiens |
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| Length | 525 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (105)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.42
- apolipoprotein A 1 measurement · score 0.42
- high density lipoprotein cholesterol measurement · score 0.42
- Red cell distribution width · score 0.36
- coronary artery disease · score 0.34
- platelet component distribution width · score 0.33
- reticulocyte count · score 0.33
- mean corpuscular volume · score 0.28
- reticulocyte measurement · score 0.27
- metabolic syndrome · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P54219-F1 | alphafold | PREDICTED | 77.18 | — |
Amino-acid sequence (525 residues)
MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY DMEFKEVNSS LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI AWMNDTASTI PPPATEAISA HKNNCLQGTG FLEEEITRVG VLFASKAVMQ LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS TVMFAFSGTY TLLFVARTLQ GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL LVGAPFGSVM YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL IGTNLFGVLA NKMGRWLCSL IGMLVVGTSL LCVPLAHNIF GLIGPNAGLG LAIGMVDSSM MPIMGHLVDL RHTSVYGSVY AIADVAFCMG FAIGPSTGGA IVKAIGFPWL MVITGVINIV YAPLCYYLRS PPAKEEKLAI LSQDCPMETR MYATQKPTKE FPLGEDSDEE PDHEE
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