Deserpidine

Catecholamine-depleting Sympatholytic — CARDIOVASCULAR SYSTEM

Key facts

Deserpidine is an ofm drug in the Catecholamine-depleting Sympatholytic class catalogued in DrugCentral. It was first approved by the FDA in 1957. DrugCentral lists 1 molecular target, including SLC18A2.

• Approval status: ofm (first approved 1957 by the FDA).
• Drug class: Catecholamine-depleting Sympatholytic.
• Molecular targets: SLC18A2 (1 listed in DrugCentral).
• ATC code: C02AA05 (Rauwolfia alkaloids).
• Molecular formula: C32H38N2O8; molecular weight 578.66 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (26)

• Acute pancreatitis
• Anuria
• Azotemia
• Cirrhosis of liver
• Dehydration
• Diabetes mellitus
• Disease of liver
• Fluid volume disorder
• Gout
• Hepatic coma
• Hypercalcemia
• Hypercholesterolemia
• Hyperparathyroidism
• Hypertriglyceridemia
• Hyperuricemia
• Hypochloremic alkalosis
• Hypokalemia
• Hypomagnesemia
• Hyponatremia
• Hypovolemia
• Impaired renal function disorder
• Neonatal hyperbilirubinemia
• Oliguria
• Secondary angle-closure glaucoma
• Sympathectomy
• Systemic lupus erythematosus

Mechanism & targets

• Established pharmacologic class: Catecholamine-depleting Sympatholytic

Molecular targets (1)

Target	Gene	Action	Activity
Synaptic vesicular amine transporter	SLC18A2	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1957-04-19	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
C02AA05	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, CENTRALLY ACTING › Rauwolfia alkaloids
C02LA03	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Rauwolfia alkaloids and diuretics in combination

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Deserpidine is on its molecule page.

• Molecular formula: C₃₂H₃₈N₂O₈
• Molecular weight: 578.66 g/mol
• CAS number: 131-01-1
• InChIKey: CVBMAZKKCSYWQR-WCGOZPBSSA-N
• PubChem CID: 8550

CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=CC=CC=C45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Deserpidine work?

Its molecular targets in DrugCentral include SLC18A2 (inhibitor).

When was Deserpidine first approved?

Deserpidine was first approved by the FDA in 1957.

What drug class does Deserpidine belong to?

Deserpidine is in the Catecholamine-depleting Sympatholytic class.

What is the chemical formula of Deserpidine?

Deserpidine has the molecular formula C32H38N2O8 and a molecular weight of 578.66 g/mol.

Sources

• DrugCentral drug card 810 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200515 — compound record and bioactivity
• PubChem CID 8550 — chemical identifiers
• DrugBank DB01089 — drug record
• FDA UNII 9016E3VB47 — substance identity
• DailyMed: FDA labels for Deserpidine — current prescribing information (label search)
• UniProt Q05940 (SLC18A2) — target protein

How this page is built: methodology · editorial policy & corrections.