About Synaptic vesicular amine transporter
Synaptic vesicular amine transporter (SLC18A2) is a protein
from Homo sapiens identified by UniProt accession
Q05940, 514 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Synaptic vesicular amine transporter |
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| UniProt accession | Q05940 |
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| Gene | SLC18A2 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (247)
Diseases linked to this target (Open Targets).
- brain dopamine-serotonin vesicular transport disease · score 0.63
- attention deficit hyperactivity disorder · score 0.61
- Infantile dystonia-parkinsonism · score 0.58
- Huntington disease · score 0.58
- movement disorder · score 0.58
- chorea · score 0.56
- hypertension · score 0.55
- major depressive disorder · score 0.53
- narcolepsy-cataplexy syndrome · score 0.53
- depressive disorder · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q05940-F1 | alphafold | PREDICTED | 77.70 | — |
Amino-acid sequence (514 residues)
MALSELALVR WLQESRRSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS IKHEKNATEI QTARPVHTAS ISDSFQSIFS YYDNSTMVTG NATRDLTLHQ TATQHMVTNA SAVPSDCPSE DKDLLNENVQ VGLLFASKAT VQLITNPFIG LLTNRIGYPI PIFAGFCIMF VSTIMFAFSS SYAFLLIARS LQGIGSSCSS VAGMGMLASV YTDDEERGNV MGIALGGLAM GVLVGPPFGS VLYEFVGKTA PFLVLAALVL LDGAIQLFVL QPSRVQPESQ KGTPLTTLLK DPYILIAAGS ICFANMGIAM LEPALPIWMM ETMCSRKWQL GVAFLPASIS YLIGTNIFGI LAHKMGRWLC ALLGMIIVGV SILCIPFAKN IYGLIAPNFG VGFAIGMVDS SMMPIMGYLV DLRHVSVYGS VYAIADVAFC MGYAIGPSAG GAIAKAIGFP WLMTIIGIID ILFAPLCFFL RSPPAKEEKM AILMDHNCPI KTKMYTQNNI QSYPIGEDEE SESD
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