Benzphetamine
Sympathomimetic Amine Anorectic
Also known as: (+)-Benzphetamine, (S)-Benzphetamine, benzphetamine HCl, benzphetamine hydrochloride
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Benzphetamine is an ofp drug in the Sympathomimetic Amine Anorectic class catalogued in DrugCentral. It was first approved by the FDA in 1960. DrugCentral lists 4 molecular targets, including ADRA2A, SLC6A2 and ADRA1A. Recorded indications include Obesity.
- Approval status: ofp (first approved 1960 by the FDA).
- Drug class: Sympathomimetic Amine Anorectic.
- Molecular targets: ADRA2A, SLC6A2, ADRA1A and SLC18A2 (4 listed in DrugCentral).
- Indications: Obesity.
- Molecular formula: C17H21N; molecular weight 239.36 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Obesity
Contraindications (17)
- Angina pectoris
- Arteriosclerotic vascular disease
- Bipolar disorder
- Breastfeeding (mother)
- Conduction disorder of the heart
- Diabetes mellitus
- Disorder of cardiovascular system
- Feeling agitated
- Glaucoma
- Heart valve disorder
- Hypertensive disorder
- Hyperthyroidism
- Mania
- Pregnancy, function
- Psychotic disorder
- Pulmonary hypertension
- Substance abuse
Mechanism & targets
| Established pharmacologic class | Sympathomimetic Amine Anorectic |
|---|
Molecular targets (4)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Alpha-2A adrenergic receptor | ADRA2A | unknown | — |
| Sodium-dependent noradrenaline transporter | SLC6A2 | releasing agent | — |
| Alpha-1A adrenergic receptor | ADRA1A | unknown | — |
| Synaptic vesicular amine transporter | SLC18A2 | inhibitor | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1960-10-26 | FDA | — | PHARMACIA AND UPJOHN |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Benzphetamine is on its molecule page.
| Molecular formula | C17H21N |
|---|---|
| Molecular weight | 239.36 g/mol |
| CAS number | 156-08-1 |
| InChIKey | YXKTVDFXDRQTKV-HNNXBMFYSA-N |
| PubChem CID | 5311017 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Benzphetamine used for?
DrugCentral lists the following indications for Benzphetamine: Obesity.
How does Benzphetamine work?
Its molecular targets in DrugCentral include ADRA2A, SLC6A2 (releasing agent), ADRA1A and SLC18A2 (inhibitor).
When was Benzphetamine first approved?
Benzphetamine was first approved by the FDA in 1960.
What drug class does Benzphetamine belong to?
Benzphetamine is in the Sympathomimetic Amine Anorectic class.
What is the chemical formula of Benzphetamine?
Benzphetamine has the molecular formula C17H21N and a molecular weight of 239.36 g/mol.
Browse: all drugs starting with B · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 329 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL3544906 — compound record and bioactivity
- PubChem CID 5311017 — chemical identifiers
- DrugBank DB00865 — drug record
- FDA UNII 0M3S43XK27 — substance identity
- DailyMed: FDA labels for Benzphetamine — current prescribing information (label search)
- UniProt P08913 (ADRA2A) — target protein
- UniProt P23975 (SLC6A2) — target protein
- UniProt P35348 (ADRA1A) — target protein
- UniProt Q05940 (SLC18A2) — target protein
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