About Muscarinic acetylcholine receptor M4
Muscarinic acetylcholine receptor M4 (CHRM4) is a protein
from Homo sapiens identified by UniProt accession
P08173, 479 residues long.
MolForge cross-references it against 0 known binders and
113 disease associations.
Target properties
| Protein name | Muscarinic acetylcholine receptor M4 |
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| UniProt accession | P08173 |
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| Gene | CHRM4 |
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| Organism | Homo sapiens |
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| Length | 479 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (113)
Diseases linked to this target (Open Targets).
- chronic obstructive pulmonary disease · score 0.60
- Hyperhidrosis · score 0.56
- peptic ulcer disease · score 0.55
- asthma · score 0.53
- cardiac arrhythmia · score 0.53
- chronic bronchitis · score 0.50
- post operative nausea and vomiting · score 0.46
- cerebral palsy · score 0.46
- schizophrenia · score 0.41
- Drooling · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08173-F1 | alphafold | PREDICTED | 75.40 | — |
Amino-acid sequence (479 residues)
MANFTPVNGS SGNQSVRLVT SSSHNRYETV EMVFIATVTG SLSLVTVVGN ILVMLSIKVN RQLQTVNNYF LFSLACADLI IGAFSMNLYT VYIIKGYWPL GAVVCDLWLA LDYVVSNASV MNLLIISFDR YFCVTKPLTY PARRTTKMAG LMIAAAWVLS FVLWAPAILF WQFVVGKRTV PDNQCFIQFL SNPAVTFGTA IAAFYLPVVI MTVLYIHISL ASRSRVHKHR PEGPKEKKAK TLAFLKSPLM KQSVKKPPPG EAAREELRNG KLEEAPPPAL PPPPRPVADK DTSNESSSGS ATQNTKERPA TELSTTEATT PAMPAPPLQP RALNPASRWS KIQIVTKQTG NECVTAIEIV PATPAGMRPA ANVARKFASI ARNQVRKKRQ MAARERKVTR TIFAILLAFI LTWTPYNVMV LVNTFCQSCI PDTVWSIGYW LCYVNSTINP ACYALCNATF KKTFRHLLLC QYRNIGTAR
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