Histamine H1 receptor (HRH1)

About Histamine H1 receptor

Histamine H1 receptor (HRH1) is a protein from Homo sapiens identified by UniProt accession P35367, 487 residues long. MolForge cross-references it against 0 known binders and 483 disease associations.

Target properties

Protein name	Histamine H1 receptor
UniProt accession	P35367
Gene	HRH1
Organism	Homo sapiens
Length	487 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (483)

Diseases linked to this target (Open Targets).

allergic rhinitis · score 0.62
seasonal allergic rhinitis · score 0.61
allergic conjunctivitis · score 0.61
allergic disease · score 0.61
Nasal congestion · score 0.61
urticaria · score 0.61
common cold · score 0.61
Cough · score 0.60
Headache · score 0.60
Pruritus · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35367-F1	alphafold	PREDICTED	69.96	—

Amino-acid sequence (487 residues)

MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLKYRT KTRASATILG AWFLSFLWVI PILGWNHFMQ QTSVRREDKC ETDFYDVTWF KVMTAIINFY LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR PENPKGDAKK PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ MLGDSQSFSR TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ YVSGLHMNRE RKAAKQLGFI MAAFILCWIP YFIFFMVIAF CKNCCNEHLH MFTIWLGYIN STLNPLIYPL CNENFKKTFK RILHIRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards