Disopyramide

Antiarrhythmic — CARDIOVASCULAR SYSTEM

Key facts

Disopyramide is an ofp drug in the Antiarrhythmic class catalogued in DrugCentral. It was first approved by the FDA in 1977. DrugCentral lists 9 molecular targets, including HRH1, KCNJ5 and SLC22A1. Recorded indications include Ventricular arrhythmia.

• Approval status: ofp (first approved 1977 by the FDA).
• Drug class: Antiarrhythmic.
• Molecular targets: HRH1, KCNJ5, SLC22A1 and KCNH2 (9 listed in DrugCentral).
• Indications: Ventricular arrhythmia.
• ATC code: C01BA03 (Antiarrhythmics, class Ia).
• Molecular formula: C21H29N3O; molecular weight 339.48 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Ventricular arrhythmia

Off-label uses (1)

• Paroxysmal supraventricular tachycardia

Contraindications (23)

• Acute nephropathy
• Angle-closure glaucoma
• Atrial fibrillation
• Atrial flutter
• Benign prostatic hyperplasia
• Cardiogenic shock
• Cardiomyopathy
• Chronic heart failure
• Complete atrioventricular block
• Congenital long QT syndrome
• Decompensated cardiac failure
• Disease of liver
• Hyperkalemia
• Hypoglycemic disorder
• Hypokalemia
• Increased Intraocular Pressure after Ocular Procedure
• Kidney disease
• Low blood pressure
• Myasthenia gravis
• Myocarditis
• Prolonged QT interval
• Retention of urine
• Second degree atrioventricular block

Mechanism & targets

• Established pharmacologic class: Antiarrhythmic

Molecular targets (9)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	unknown	Ki 5.57
G protein-activated inward rectifier potassium channel 4	KCNJ5	unknown	IC50 4.92
Solute carrier family 22 member 1	SLC22A1	unknown	IC50 4.09
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 4.04
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	HCN4	unknown	IC50 3.60
Muscarinic acetylcholine receptor M2	CHRM2	unknown	—
Muscarinic acetylcholine receptor M1	CHRM1	unknown	—
Sodium channel protein type 5 subunit alpha	SCN5A	blocker	—
Muscarinic acetylcholine receptor M3	CHRM3	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1977-09-01	FDA	—	GD SEARLE LLC

ATC classification

ATC code	Therapeutic hierarchy
C01BA03	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › ANTIARRHYTHMICS, CLASS I AND III › Antiarrhythmics, class Ia

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Electrocardiogram QT prolonged	60.1
Bradycardia	51.2
Torsade de pointes	45.3
Hypoglycaemia	41.7
Atrial fibrillation	39.0
Left atrial volume increased	36.9
Drug ineffective	33.0
Drug ineffective for unapproved indication	30.0
Ventricular tachycardia	30.0
Mitral valve stenosis	28.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Disopyramide is on its molecule page.

• Molecular formula: C₂₁H₂₉N₃O
• Molecular weight: 339.48 g/mol
• CAS number: 3737-09-5
• InChIKey: UVTNFZQICZKOEM-UHFFFAOYSA-N
• PubChem CID: 3114

CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C1=CC=CC=N1)C(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Disopyramide used for?

DrugCentral lists the following indications for Disopyramide: Ventricular arrhythmia.

How does Disopyramide work?

Its molecular targets in DrugCentral include HRH1, KCNJ5, SLC22A1 and KCNH2.

When was Disopyramide first approved?

Disopyramide was first approved by the FDA in 1977.

What drug class does Disopyramide belong to?

Disopyramide is in the Antiarrhythmic class.

What is the chemical formula of Disopyramide?

Disopyramide has the molecular formula C21H29N3O and a molecular weight of 339.48 g/mol.

Sources

• DrugCentral drug card 926 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201020 — compound record and bioactivity
• PubChem CID 3114 — chemical identifiers
• DrugBank DB00280 — drug record
• FDA UNII GFO928U8MQ — substance identity
• DailyMed: FDA labels for Disopyramide — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein
• UniProt P48544 (KCNJ5) — target protein
• UniProt O15245 (SLC22A1) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt Q9Y3Q4 (HCN4) — target protein
• UniProt P08172 (CHRM2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.