About G protein-activated inward rectifier potassium channel 4
G protein-activated inward rectifier potassium channel 4 (KCNJ5) is a protein
from Homo sapiens identified by UniProt accession
P48544, 419 residues long.
MolForge cross-references it against 0 known binders and
293 disease associations.
Target properties
| Protein name | G protein-activated inward rectifier potassium channel 4 |
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| UniProt accession | P48544 |
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| Gene | KCNJ5 |
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| Organism | Homo sapiens |
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| Length | 419 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (293)
Diseases linked to this target (Open Targets).
- familial hyperaldosteronism type III · score 0.73
- atrial fibrillation · score 0.69
- aldosterone-producing adenoma · score 0.51
- Romano-Ward syndrome · score 0.49
- Prolonged QT interval · score 0.49
- heart rate · score 0.48
- long QT syndrome 13 · score 0.46
- electrocardiography · score 0.46
- atrial flutter · score 0.45
- cardiac arrhythmia · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48544-F1 | alphafold | PREDICTED | 81.31 | — |
Amino-acid sequence (419 residues)
MAGDSRNAMN QDMEIGVTPW DPKKIPKQAR DYVPIATDRT RLLAEGKKPR QRYMEKSGKC NVHHGNVQET YRYLSDLFTT LVDLKWRFNL LVFTMVYTVT WLFFGFIWWL IAYIRGDLDH VGDQEWIPCV ENLSGFVSAF LFSIETETTI GYGFRVITEK CPEGIILLLV QAILGSIVNA FMVGCMFVKI SQPKKRAETL MFSNNAVISM RDEKLCLMFR VGDLRNSHIV EASIRAKLIK SRQTKEGEFI PLNQTDINVG FDTGDDRLFL VSPLIISHEI NQKSPFWEMS QAQLHQEEFE VVVILEGMVE ATGMTCQARS SYMDTEVLWG HRFTPVLTLE KGFYEVDYNT FHDTYETNTP SCCAKELAEM KREGRLLQYL PSPPLLGGCA EAGLDAEAEQ NEEDEPKGLG GSREARGSV
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