Ajmaline

CARDIOVASCULAR SYSTEM

Key facts

Ajmaline is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including KCNA5, KCND3 and CYP2D6. Recorded indications include Cardiac arrhythmia, Supraventricular arrhythmia and Ventricular arrhythmia.

• Molecular targets: KCNA5, KCND3, CYP2D6 and SCN5A (4 listed in DrugCentral).
• Indications: Cardiac arrhythmia, Supraventricular arrhythmia and Ventricular arrhythmia.
• ATC code: C01BA05 (Antiarrhythmics, class Ia).
• Molecular formula: C20H26N2O2; molecular weight 326.44 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Cardiac arrhythmia
• Supraventricular arrhythmia
• Ventricular arrhythmia

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Potassium voltage-gated channel subfamily A member 5	KCNA5	inhibitor	IC50 7.77
Potassium voltage-gated channel subfamily D member 3	KCND3	inhibitor	IC50 7.58
Cytochrome P450 2D6	CYP2D6	unknown	IC50 6.00
Sodium channel protein type 5 subunit alpha	SCN5A	inhibitor	—

ATC classification

ATC code	Therapeutic hierarchy
C01BA05	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › ANTIARRHYTHMICS, CLASS I AND III › Antiarrhythmics, class Ia

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Ajmaline is on its molecule page.

• Molecular formula: C₂₀H₂₆N₂O₂
• Molecular weight: 326.44 g/mol
• CAS number: —
• InChIKey: CJDRUOGAGYHKKD-RQBLFBSQSA-N
• PubChem CID: 6100671

CC[C@H]1[C@@H]2C[C@H]3[C@@H]4N(C)C5=CC=CC=C5[C@]44C[C@@H]([C@H]2[C@H]4O)N3[C@@H]1O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Ajmaline used for?

DrugCentral lists the following indications for Ajmaline: Cardiac arrhythmia, Supraventricular arrhythmia and Ventricular arrhythmia.

How does Ajmaline work?

Its molecular targets in DrugCentral include KCNA5 (inhibitor), KCND3 (inhibitor), CYP2D6 and SCN5A (inhibitor).

What is the chemical formula of Ajmaline?

Ajmaline has the molecular formula C20H26N2O2 and a molecular weight of 326.44 g/mol.

Sources

• DrugCentral drug card 100 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL5314404 — compound record and bioactivity
• PubChem CID 6100671 — chemical identifiers
• DrugBank DB01426 — drug record
• FDA UNII 1PON08459R — substance identity
• UniProt P22460 (KCNA5) — target protein
• UniProt Q9UK17 (KCND3) — target protein
• UniProt P10635 (CYP2D6) — target protein
• UniProt Q14524 (SCN5A) — target protein

How this page is built: methodology · editorial policy & corrections.