A-type voltage-gated potassium channel KCND3 (KCND3)

About A-type voltage-gated potassium channel KCND3

A-type voltage-gated potassium channel KCND3 (KCND3) is a protein from Homo sapiens identified by UniProt accession Q9UK17, 655 residues long. MolForge cross-references it against 5 known binders and 283 disease associations.

Target properties

Protein name	A-type voltage-gated potassium channel KCND3
UniProt accession	Q9UK17
Gene	KCND3
Organism	Homo sapiens
Length	655 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). Approved drug exists

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs acting on this target (1)

Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.

Disease associations (283)

Diseases linked to this target (Open Targets).

spinocerebellar ataxia type 19/22 · score 0.80
atrial fibrillation · score 0.70
multiple sclerosis · score 0.59
Brugada syndrome 9 · score 0.58
Myasthenia gravis · score 0.57
electrocardiography · score 0.52
atrial flutter · score 0.47
Muscle weakness · score 0.46
small cell carcinoma · score 0.46
cardiac arrhythmia · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK17-F1	alphafold	PREDICTED	70.44	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UK17.

Amino-acid sequence (655 residues)

MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR FQTWRTTLER YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT GKLHYPRYEC ISAYDDELAF YGILPEIIGD CCYEEYKDRK RENAERLMDD NDSENNQESM PSLSFRQTMW RAFENPHTST LALVFYYVTG FFIAVSVITN VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE YLLRLFAAPS RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK FTSIPASFWY TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP VIVSNFSRIY HQNQRADKRR AQKKARLARI RVAKTGSSNA YLHSKRNGLL NEALELTGTP EEEHMGKTTS LIESQHHHLL HCLEKTTGLS YLVDDPLLSV RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHP GLTTTCCSRR SKKTTHLPNS NLPATRLRSM QELSTIHIQG SEQPSLTTSR SSLNLKADDG LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSIASNVV KVSAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards