Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4)
Homo sapiens — UniProt Q9Y3Q4
Data last refreshed: (UniProt release unknown)
Key facts
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) is a protein from Homo sapiens identified by UniProt accession Q9Y3Q4, 1203 residues long. MolForge cross-references it against 14 known binders and 233 disease associations.
- UniProt accession: Q9Y3Q4; gene symbol HCN4.
- Organism: Homo sapiens.
- Length: 1203 amino acids.
- Approved drugs acting on it (DrugCentral): Dronedarone.
- Top disease associations (Open Targets): sick sinus syndrome 2, autosomal dominant, atrial fibrillation and Brugada syndrome 8.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
|---|---|
| UniProt accession | Q9Y3Q4 |
| Gene | HCN4 |
| Organism | Homo sapiens |
| Length | 1203 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (233)
Diseases linked to this target (Open Targets).
- sick sinus syndrome 2, autosomal dominant · score 0.72
- atrial fibrillation · score 0.72
- Brugada syndrome 8 · score 0.59
- heart failure · score 0.58
- congestive heart failure · score 0.52
- Abnormality of the cardiovascular system · score 0.50
- angina pectoris · score 0.50
- cardiovascular disease · score 0.49
- coronary artery disease · score 0.46
- atrial flutter · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3Q4-F1 | alphafold | PREDICTED | 59.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3Q4.
Amino-acid sequence (1203 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target HCN4?
DrugCentral lists 1 approved drug whose mechanism of action is HCN4: Dronedarone.
Which diseases are associated with HCN4?
The strongest Open Targets associations for HCN4 are sick sinus syndrome 2, autosomal dominant, atrial fibrillation, Brugada syndrome 8, heart failure and congestive heart failure.
How long is the HCN4 protein?
The Homo sapiens HCN4 protein (UniProt Q9Y3Q4) is 1203 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3Q4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3Q4 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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