Nomifensine

NERVOUS SYSTEM

Key facts

Nomifensine is a drug catalogued in DrugCentral. DrugCentral lists 12 molecular targets, including Slc6a2, NET and SLC6A2.

• Molecular targets: Slc6a2, NET, SLC6A2 and Slc6a3 (12 listed in DrugCentral).
• ATC code: N06AX04 (Other antidepressants).
• Molecular formula: C16H18N2; molecular weight 238.33 g/mol.

Mechanism & targets

Molecular targets (12)

Target	Gene	Action	Activity
Transporter	Slc6a2	unknown	Ki 8.42
Transporter	NET	unknown	Ki 8.40
Sodium-dependent noradrenaline transporter	SLC6A2	inhibitor	Ki 7.67
Sodium-dependent dopamine transporter	Slc6a3	unknown	Ki 7.59
Sodium-dependent dopamine transporter	SLC6A3	inhibitor	Ki 7.31
Sodium-dependent serotonin transporter	Slc6a4	unknown	Ki 6.06
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 5.93
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 5.85
Histamine H1 receptor	HRH1	unknown	Ki 5.57
Hemoglobin HbA	HBB|HBA1	unknown	Km 4.68
Myeloperoxidase	MPO	unknown	Km 3.96
Amine oxidase [flavin-containing] A	MAOA	unknown	Km 2.95

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
N06AX04	NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Other antidepressants

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Nomifensine is on its molecule page.

• Molecular formula: C₁₆H₁₈N₂
• Molecular weight: 238.33 g/mol
• CAS number: 24526-64-5
• InChIKey: XXPANQJNYNUNES-UHFFFAOYSA-N
• PubChem CID: 4528

CN1CC(C2=CC=CC=C2)C2=CC=CC(N)=C2C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Nomifensine work?

Its molecular targets in DrugCentral include Slc6a2, NET, SLC6A2 (inhibitor) and Slc6a3.

What is the chemical formula of Nomifensine?

Nomifensine has the molecular formula C16H18N2 and a molecular weight of 238.33 g/mol.

Sources

• DrugCentral drug card 1958 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1256842 — compound record and bioactivity
• PubChem CID 4528 — chemical identifiers
• DrugBank DB04821 — drug record
• FDA UNII 1LGS5JRP31 — substance identity
• DailyMed: FDA labels for Nomifensine — current prescribing information (label search)
• UniProt P23975 (SLC6A2) — target protein
• UniProt Q01959 (SLC6A3) — target protein
• UniProt P08908 (HTR1A) — target protein
• UniProt P31645 (SLC6A4) — target protein
• UniProt P35367 (HRH1) — target protein
• UniProt P05164 (MPO) — target protein

How this page is built: methodology · editorial policy & corrections.