Esketamine

NERVOUS SYSTEM

Key facts

Esketamine is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 2019. DrugCentral lists 1 molecular target, including Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a. Recorded indications include Depressive disorder.

• Approval status: ofp (first approved 2019 by the FDA).
• Molecular targets: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a (1 listed in DrugCentral).
• Indications: Depressive disorder.
• ATC code: N01AX14 (Other general anesthetics).
• Molecular formula: C13H16ClNO; molecular weight 237.73 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Depressive disorder

Contraindications (2)

• Aneurysm
• Arteriovenous malformation

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Glutamate NMDA receptor	Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a	antagonist	Ki 6.16

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2019-12-18	EMA	—	Janssen-Cilag International N.V.
2019-05-03	FDA	—	JANSSEN PHARMS

ATC classification

ATC code	Therapeutic hierarchy
N01AX14	NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Other general anesthetics
N06AX27	NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Other antidepressants

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Dissociation	20305.6
Sedation	9637.0
Suicidal ideation	2250.3
Hospitalisation	1077.1
Hypertension	628.5
Incorrect dose administered by device	559.7
Suicide attempt	530.2
Panic attack	494.6
Device issue	457.9
Blood pressure increased	449.7
Anxiety	404.1
Dissociative disorder	403.4

Chemical structure

• Molecular formula: C₁₃H₁₆ClNO
• Molecular weight: 237.73 g/mol
• CAS number: 33643-46-8
• InChIKey: YQEZLKZALYSWHR-ZDUSSCGKSA-N
• PubChem CID: 182137

CN[C@@]1(CCCCC1=O)C1=C(Cl)C=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Esketamine used for?

DrugCentral lists the following indications for Esketamine: Depressive disorder.

How does Esketamine work?

Its molecular targets in DrugCentral include Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a (antagonist).

When was Esketamine first approved?

Esketamine was first approved by the FDA in 2019.

What is the chemical formula of Esketamine?

Esketamine has the molecular formula C13H16ClNO and a molecular weight of 237.73 g/mol.

Sources

• DrugCentral drug card 4468 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2364609 — compound record and bioactivity
• PubChem CID 182137 — chemical identifiers
• DrugBank DB11823 — drug record
• FDA UNII 50LFG02TXD — substance identity
• DailyMed: FDA labels for Esketamine — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.