Alfaxalone
NERVOUS SYSTEM
Also known as: alfadione, alfaxolone, alphaxalone
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Alfaxalone is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1972. DrugCentral lists 4 molecular targets, including Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre, GABRG2|GABRA2|GABRB2 and GABRA1|GABRG2|GABRB2.
- Molecular targets: Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre, GABRG2|GABRA2|GABRB2, GABRA1|GABRG2|GABRB2 and SLC6A1 (4 listed in DrugCentral).
- ATC code: N01AX05 (Other general anesthetics).
- Molecular formula: C21H32O3; molecular weight 332.48 g/mol.
Mechanism & targets
Molecular targets (4)
| Target | Gene | Action | Activity |
|---|---|---|---|
| GABA-A receptor; anion channel | Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre | unknown | IC50 6.52 |
| GABA A receptor alpha-2/beta-2/gamma-2 | GABRG2|GABRA2|GABRB2 | unknown | EC50 5.70 |
| GABA-A receptor alpha-1/beta-2/gamma-2 | GABRA1|GABRG2|GABRB2 | unknown | EC50 5.70 |
| Sodium- and chloride-dependent GABA transporter 1 | SLC6A1 | unknown | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1972-01-01 | YEAR INTRODUCED | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
N01AX05 | NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Other general anesthetics |
Chemical structure
| Molecular formula | C21H32O3 |
|---|---|
| Molecular weight | 332.48 g/mol |
| CAS number | 23930-19-0 |
| InChIKey | DUHUCHOQIDJXAT-OLVMNOGESA-N |
| PubChem CID | 104845 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
How does Alfaxalone work?
Its molecular targets in DrugCentral include Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre, GABRG2|GABRA2|GABRB2, GABRA1|GABRG2|GABRB2 and SLC6A1.
When was Alfaxalone first approved?
Alfaxalone was first approved by the YEAR INTRODUCED in 1972.
What is the chemical formula of Alfaxalone?
Alfaxalone has the molecular formula C21H32O3 and a molecular weight of 332.48 g/mol.
Browse: all drugs starting with A · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 133 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL190279 — compound record and bioactivity
- PubChem CID 104845 — chemical identifiers
- DrugBank DB11371 — drug record
- FDA UNII BD07M97B2A — substance identity
- UniProt P30531 (SLC6A1) — target protein
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