About Sodium- and chloride-dependent GABA transporter 1
Sodium- and chloride-dependent GABA transporter 1 (SLC6A1) is a protein
from Homo sapiens identified by UniProt accession
P30531, 599 residues long.
MolForge cross-references it against 0 known binders and
276 disease associations.
Target properties
| Protein name | Sodium- and chloride-dependent GABA transporter 1 |
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| UniProt accession | P30531 |
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| Gene | SLC6A1 |
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| Organism | Homo sapiens |
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| Length | 599 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (276)
Diseases linked to this target (Open Targets).
- myoclonic-astatic epilepsy · score 0.77
- Seizure · score 0.59
- genetic disorder · score 0.54
- Intellectual disability · score 0.49
- Neurodevelopmental delay · score 0.48
- social anxiety disorder · score 0.46
- anxiety · score 0.39
- epilepsy · score 0.38
- Neurodevelopmental disorder · score 0.38
- partial epilepsy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30531-F1 | alphafold | PREDICTED | 87.96 | — |
Amino-acid sequence (599 residues)
MATNGSKVAD GQISTEVSEA PVANDKPKTL VVKVQKKAAD LPDRDTWKGR FDFLMSCVGY AIGLGNVWRF PYLCGKNGGG AFLIPYFLTL IFAGVPLFLL ECSLGQYTSI GGLGVWKLAP MFKGVGLAAA VLSFWLNIYY IVIISWAIYY LYNSFTTTLP WKQCDNPWNT DRCFSNYSMV NTTNMTSAVV EFWERNMHQM TDGLDKPGQI RWPLAITLAI AWILVYFCIW KGVGWTGKVV YFSATYPYIM LIILFFRGVT LPGAKEGILF YITPNFRKLS DSEVWLDAAT QIFFSYGLGL GSLIALGSYN SFHNNVYRDS IIVCCINSCT SMFAGFVIFS IVGFMAHVTK RSIADVAASG PGLAFLAYPE AVTQLPISPL WAILFFSMLL MLGIDSQFCT VEGFITALVD EYPRLLRNRR ELFIAAVCII SYLIGLSNIT QGGIYVFKLF DYYSASGMSL LFLVFFECVS ISWFYGVNRF YDNIQEMVGS RPCIWWKLCW SFFTPIIVAG VFIFSAVQMT PLTMGNYVFP KWGQGVGWLM ALSSMVLIPG YMAYMFLTLK GSLKQRIQVM VQPSEDIVRP ENGPEQPQAG SSTSKEAYI
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