Gepirone

NERVOUS SYSTEM

Key facts

Gepirone is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2023. DrugCentral lists 6 molecular targets, including HTR1A, Htr1a and DRD2. Recorded indications include Major depressive disorder.

• Approval status: onp (first approved 2023 by the FDA).
• Molecular targets: HTR1A, Htr1a, DRD2 and Htr1a|Htr1b|Htr1d|Htr1f (6 listed in DrugCentral).
• Indications: Major depressive disorder.
• ATC code: N06AX19 (Other antidepressants).
• Molecular formula: C19H29N5O2; molecular weight 359.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Major depressive disorder

Contraindications (4)

• Congenital long QT syndrome
• Monoamine oxidase inhibitor
• Prolonged QT interval
• Severe hepatic impairment

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 1A	HTR1A	agonist	Ki 7.89
5-hydroxytryptamine receptor 1A	Htr1a	unknown	Ki 7.50
D(2) dopamine receptor	DRD2	unknown	Ki 7.24
Serotonin 1 (5-HT1) receptor	Htr1a|Htr1b|Htr1d|Htr1f	unknown	IC50 6.17
Adrenergic receptor alpha-1	Adra1b|Adra1d|Adra1a	unknown	Ki 5.62
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 5.44

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2023-09-22	FDA	—	FABRE-KRAMER PHARMACEUTICALS, INC.

ATC classification

ATC code	Therapeutic hierarchy
N06AX19	NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Other antidepressants

Chemical structure

• Molecular formula: C₁₉H₂₉N₅O₂
• Molecular weight: 359.47 g/mol
• CAS number: 83928-76-1
• InChIKey: QOIGKGMMAGJZNZ-UHFFFAOYSA-N
• PubChem CID: 55191

CC1(C)CC(=O)N(CCCCN2CCN(CC2)C2=NC=CC=N2)C(=O)C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Gepirone used for?

DrugCentral lists the following indications for Gepirone: Major depressive disorder.

How does Gepirone work?

Its molecular targets in DrugCentral include HTR1A (agonist), Htr1a, DRD2 and Htr1a|Htr1b|Htr1d|Htr1f.

When was Gepirone first approved?

Gepirone was first approved by the FDA in 2023.

What is the chemical formula of Gepirone?

Gepirone has the molecular formula C19H29N5O2 and a molecular weight of 359.47 g/mol.

Sources

• DrugCentral drug card 4562 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1204187 — compound record and bioactivity
• PubChem CID 55191 — chemical identifiers
• DrugBank DB12184 — drug record
• FDA UNII JW5Y7B8Z18 — substance identity
• DailyMed: FDA labels for Gepirone — current prescribing information (label search)
• UniProt P08908 (HTR1A) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P28223 (HTR2A) — target protein

How this page is built: methodology · editorial policy & corrections.