5-hydroxytryptamine receptor 2A (HTR2A)

About 5-hydroxytryptamine receptor 2A

5-hydroxytryptamine receptor 2A (HTR2A) is a protein from Homo sapiens identified by UniProt accession P28223, 471 residues long. MolForge cross-references it against 0 known binders and 478 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 2A
UniProt accession	P28223
Gene	HTR2A
Organism	Homo sapiens
Length	471 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (478)

Diseases linked to this target (Open Targets).

major depressive disorder · score 0.63
schizophrenia · score 0.62
unipolar depression · score 0.61
bipolar disorder · score 0.61
psychosis · score 0.61
autism · score 0.61
schizoaffective disorder · score 0.61
bipolar I disorder · score 0.60
Agitation · score 0.60
depressive disorder · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28223-F1	alphafold	PREDICTED	73.74	—

Amino-acid sequence (471 residues)

MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH REPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEEASKDN SDGVNEKVSC V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards