About Amine oxidase [flavin-containing] A
Amine oxidase [flavin-containing] A (MAOA) is a protein
from Homo sapiens identified by UniProt accession
P21397, 527 residues long.
MolForge cross-references it against 0 known binders and
381 disease associations.
Target properties
| Protein name | Amine oxidase [flavin-containing] A |
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| UniProt accession | P21397 |
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| Gene | MAOA |
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| Organism | Homo sapiens |
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| Length | 527 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (381)
Diseases linked to this target (Open Targets).
- Brunner syndrome · score 0.78
- Monoamine oxidase A deficiency · score 0.72
- unipolar depression · score 0.58
- major depressive disorder · score 0.55
- depressive disorder · score 0.51
- bipolar disorder · score 0.47
- melancholia · score 0.46
- autism · score 0.37
- mental or behavioural disorder · score 0.37
- hypertension · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21397-F1 | alphafold | PREDICTED | 97.01 | — |
Amino-acid sequence (527 residues)
MENQEKASIA GHMFDVVVIG GGISGLSAAK LLTEYGVSVL VLEARDRVGG RTYTIRNEHV DYVDVGGAYV GPTQNRILRL SKELGIETYK VNVSERLVQY VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT IDNMGKEIPT DAPWEAQHAD KWDKMTMKEL IDKICWTKTA RRFAYLFVNI NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSV TNGGQERKFV GGSGQVSERI MDLLGDQVKL NHPVTHVDQS SDNIIIETLN HEHYECKYVI NAIPPTLTAK IHFRPELPAE RNQLIQRLPM GAVIKCMMYY KEAFWKKKDY CGCMIIEDED APISITLDDT KPDGSLPAIM GFILARKADR LAKLHKEIRK KKICELYAKV LGSQEALHPV HYEEKNWCEE QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI FFAGTETATK WSGYMEGAVE AGERAAREVL NGLGKVTEKD IWVQEPESKD VPAVEITHTF WERNLPSVSG LLKIIGFSTS VTALGFVLYK YKLLPRS
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