Troglitazone

ALIMENTARY TRACT AND METABOLISM

Key facts

Troglitazone is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1997. DrugCentral lists 23 molecular targets, including FOXM1, PPARG and HTR2B. Recorded indications include Diabetes mellitus type 2.

• Approval status: ofm (first approved 1997 by the FDA).
• Molecular targets: FOXM1, PPARG, HTR2B and CA2 (23 listed in DrugCentral).
• Indications: Diabetes mellitus type 2.
• ATC code: A10BG01 (Thiazolidinediones).
• Molecular formula: C24H27NO5S; molecular weight 441.55 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Diabetes mellitus type 2

Mechanism & targets

Molecular targets (23)

Target	Gene	Action	Activity
Forkhead box protein M1	FOXM1	unknown	Ki 7.28
Peroxisome proliferator-activated receptor gamma	PPARG	agonist	EC50 6.27
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 6.08
Carbonic anhydrase 2	CA2	unknown	IC50 6.01
Mitogen-activated protein kinase 1	MAPK1	unknown	IC50 5.91
Aldose reductase	Akr1b1	unknown	IC50 5.69
Bile salt export pump	ABCB11	unknown	IC50 5.57
Adenosine receptor A3	ADORA3	unknown	Ki 5.53
Thromboxane-A synthase	TBXAS1	unknown	IC50 5.53
Cytochrome P450 2C9	CYP2C9	unknown	IC50 5.40
Indoleamine 2,3-dioxygenase 2	Ido2	unknown	IC50 5.35
Amine oxidase [flavin-containing] A	Maoa	unknown	Ki 5.32
Amine oxidase [flavin-containing] B	MAOB	unknown	Ki 5.02
Amine oxidase [flavin-containing] A	MAOA	unknown	Ki 4.98
Bile salt export pump	Abcb11	unknown	IC50 4.97
Amine oxidase [flavin-containing] B	Maob	unknown	Ki 4.96
UDP-glucuronosyltransferase 1-6	UGT1A6	unknown	Ki 4.70
Polyunsaturated fatty acid lipoxygenase ALOX15	Alox15	unknown	IC50 4.70
Tyrosine-protein phosphatase non-receptor type 1	PTPN1	unknown	IC50 4.26
Indoleamine 2,3-dioxygenase 1	Ido1	unknown	IC50 4.21

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1997-01-29	FDA	—	PFIZER PHARMS

ATC classification

ATC code	Therapeutic hierarchy
A10BG01	ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS › Thiazolidinediones

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Troglitazone is on its molecule page.

• Molecular formula: C₂₄H₂₇NO₅S
• Molecular weight: 441.55 g/mol
• CAS number: —
• InChIKey: GXPHKUHSUJUWKP-UHFFFAOYSA-N
• PubChem CID: 5591

CC1=C(O)C(C)=C2CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)OC2=C1C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Troglitazone used for?

DrugCentral lists the following indications for Troglitazone: Diabetes mellitus type 2.

How does Troglitazone work?

Its molecular targets in DrugCentral include FOXM1, PPARG (agonist), HTR2B and CA2.

When was Troglitazone first approved?

Troglitazone was first approved by the FDA in 1997.

What is the chemical formula of Troglitazone?

Troglitazone has the molecular formula C24H27NO5S and a molecular weight of 441.55 g/mol.

Sources

• DrugCentral drug card 2767 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL408 — compound record and bioactivity
• PubChem CID 5591 — chemical identifiers
• DrugBank DB00197 — drug record
• FDA UNII I66ZZ0ZN0E — substance identity
• DailyMed: FDA labels for Troglitazone — current prescribing information (label search)
• UniProt Q08050 (FOXM1) — target protein
• UniProt P37231 (PPARG) — target protein
• UniProt P41595 (HTR2B) — target protein
• UniProt P00918 (CA2) — target protein
• UniProt P28482 (MAPK1) — target protein
• UniProt O95342 (ABCB11) — target protein

How this page is built: methodology · editorial policy & corrections.