About Amine oxidase [flavin-containing] B
Amine oxidase [flavin-containing] B (MAOB) is a protein
from Homo sapiens identified by UniProt accession
P27338, 520 residues long.
MolForge cross-references it against 0 known binders and
387 disease associations.
Target properties
| Protein name | Amine oxidase [flavin-containing] B |
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| UniProt accession | P27338 |
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| Gene | MAOB |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (387)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.61
- unipolar depression · score 0.56
- major depressive disorder · score 0.56
- depressive disorder · score 0.51
- bipolar disorder · score 0.51
- melancholia · score 0.46
- schizophrenia · score 0.45
- retinal detachment · score 0.37
- hypertension · score 0.37
- neurodegenerative disease · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27338-F1 | alphafold | PREDICTED | 95.60 | — |
Amino-acid sequence (520 residues)
MSNKCDVVVV GGGISGMAAA KLLHDSGLNV VVLEARDRVG GRTYTLRNQK VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH HVKGKSYPFR GPFPPVWNPI TYLDHNNFWR TMDDMGREIP SDAPWKAPLA EEWDNMTMKE LLDKLCWTES AKQLATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS TTNGGQERKF VGGSGQVSER IMDLLGDRVK LERPVIYIDQ TRENVLVETL NHEMYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQMITRVP LGSVIKCIVY YKEPFWRKKD YCGTMIIDGE EAPVAYTLDD TKPEGNYAAI MGFILAHKAR KLARLTKEER LKKLCELYAK VLGSLEALEP VHYEEKNWCE EQYSGGCYTT YFPPGILTQY GRVLRQPVDR IYFAGTETAT HWSGYMEGAV EAGERAAREI LHAMGKIPED EIWQSEPESV DVPAQPITTT FLERHLPSVP GLLRLIGLTT IFSATALGFL AHKRGLLVRV
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