About Forkhead box protein M1
Forkhead box protein M1 (FOXM1) is a protein
from Homo sapiens identified by UniProt accession
Q08050, 763 residues long.
MolForge cross-references it against 0 known binders and
529 disease associations.
Target properties
| Protein name | Forkhead box protein M1 |
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| UniProt accession | Q08050 |
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| Gene | FOXM1 |
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| Organism | Homo sapiens |
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| Length | 763 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (529)
Diseases linked to this target (Open Targets).
- cancer · score 0.49
- mean corpuscular volume · score 0.33
- testosterone measurement · score 0.28
- Parkinson disease · score 0.28
- multiple sclerosis · score 0.27
- Alzheimer disease · score 0.27
- lysosomal storage disease · score 0.27
- neurodegenerative disease · score 0.27
- body height · score 0.26
- mean reticulocyte volume · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q08050-F1 | alphafold | PREDICTED | 50.21 | — |
Amino-acid sequence (763 residues)
MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA PKVLLAEEGI APLSSAGPGK EEKLLFGEGF SPLLPVQTIK EEEIQPGEEM PHLARPIKVE SPPLEEWPSP APSFKEESSH SWEDSSQSPT PRPKKSYSGL RSPTRCVSEM LVIQHRERRE RSRSRRKQHL LPPCVDEPEL LFSEGPSTSR WAAELPFPAD SSDPASQLSY SQEVGGPFKT PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTSQGASDPL PDPLGLMDLS TTPLQSAPPL ESPQRLLSSE PLDLISVPFG NSSPSDIDVP KPGSPEPQVS GLAANRSLTE GLVLDTMNDS LSKILLDISF PGLDEDPLGP DNINWSQFIP ELQ
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