About Carbonic anhydrase 2
Carbonic anhydrase 2 (CA2) is a protein
from Homo sapiens identified by UniProt accession
P00918, 260 residues long.
MolForge cross-references it against 0 known binders and
618 disease associations.
Target properties
| Protein name | Carbonic anhydrase 2 |
|---|
| UniProt accession | P00918 |
|---|
| Gene | CA2 |
|---|
| Organism | Homo sapiens |
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| Length | 260 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (618)
Diseases linked to this target (Open Targets).
- Osteopetrosis with renal tubular acidosis · score 0.77
- autosomal recessive osteopetrosis 3 · score 0.76
- glaucoma · score 0.62
- epilepsy · score 0.60
- ocular hypertension · score 0.60
- open-angle glaucoma · score 0.60
- altitude sickness · score 0.60
- migraine disorder · score 0.60
- Seizure · score 0.60
- angle-closure glaucoma · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00918-F1 | alphafold | PREDICTED | 97.37 | — |
Amino-acid sequence (260 residues)
MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP PLLECVTWIV LKEPISVSSE QVLKFRKLNF NGEGEPEELM VDNWRPAQPL KNRQIKASFK
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