Acetohydroxamic acid
Urease Inhibitor — GENITO URINARY SYSTEM AND SEX HORMONES
Also known as: acetohydroximic acid, acetylhydroxamic acid, N-Acetyl hydroxyacetamide, N-acetylhydroxylamine, N-hydroxyacetamide
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Acetohydroxamic acid is a drug in the Urease Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 1983. Its mechanism of action is classified as Urease Inhibitors. DrugCentral lists 4 molecular targets, including Urease, ureB and CA2. Recorded indications include Struvite Renal Calculi and Urinary tract infectious disease.
- Drug class: Urease Inhibitor.
- Mechanism of action: Urease Inhibitors.
- Molecular targets: Urease, ureB, CA2 and ureA|ureB|ureC (4 listed in DrugCentral).
- Indications: Struvite Renal Calculi and Urinary tract infectious disease.
- ATC code: G04BX03 (Other urologicals).
- Molecular formula: C2H5NO2; molecular weight 75.07 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (2)
- Struvite Renal Calculi
- Urinary tract infectious disease
Contraindications (8)
- Acute nephropathy
- Alcoholism
- Anemia
- Hemolytic anemia
- Leukopenia
- Phlebitis
- Pregnancy, function
- Thrombocytopenic disorder
Mechanism & targets
| Mechanism of action (MoA) | Urease Inhibitors |
|---|---|
| Established pharmacologic class | Urease Inhibitor |
Molecular targets (4)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Urease | — | unknown | IC50 4.76 |
| Urease subunit beta | ureB | unknown | IC50 4.76 |
| Carbonic anhydrase 2 | CA2 | unknown | IC50 4.33 |
| Bacterial urease | ureA|ureB|ureC | inhibitor | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1983-05-31 | FDA | — | MISSION PHARMA |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
G04BX03 | GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Other urologicals |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Acetohydroxamic acid is on its molecule page.
| Molecular formula | C2H5NO2 |
|---|---|
| Molecular weight | 75.07 g/mol |
| CAS number | 546-88-3 |
| InChIKey | RRUDCFGSUDOHDG-UHFFFAOYSA-N |
| PubChem CID | 1990 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Acetohydroxamic acid used for?
DrugCentral lists the following indications for Acetohydroxamic acid: Struvite Renal Calculi and Urinary tract infectious disease.
How does Acetohydroxamic acid work?
Acetohydroxamic acid is classified as Urease Inhibitors; its molecular targets in DrugCentral include Urease, ureB, CA2 and ureA|ureB|ureC (inhibitor).
When was Acetohydroxamic acid first approved?
Acetohydroxamic acid was first approved by the FDA in 1983.
What drug class does Acetohydroxamic acid belong to?
Acetohydroxamic acid is in the Urease Inhibitor class.
What is the chemical formula of Acetohydroxamic acid?
Acetohydroxamic acid has the molecular formula C2H5NO2 and a molecular weight of 75.07 g/mol.
Browse: all drugs starting with A · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 58 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL734 — compound record and bioactivity
- PubChem CID 1990 — chemical identifiers
- DrugBank DB00551 — drug record
- FDA UNII 4RZ82L2GY5 — substance identity
- DailyMed: FDA labels for Acetohydroxamic acid — current prescribing information (label search)
- UniProt P00918 (CA2) — target protein
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