Phenazopyridine

GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Phenazopyridine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 2001. DrugCentral lists 4 molecular targets, including REP, Snake venom metalloproteinase Bap1 and SARM1. Recorded indications include Dysuria and Urinary Tract Irritation.

• Approval status: ofm (first approved 2001 by the FDA).
• Molecular targets: REP, Snake venom metalloproteinase Bap1, SARM1 and SCN1A|SCN4A|SCN7A|SCN5A|SCN9A|SCN2A|SCN3A|SCN11A|SCN8A|SCN10A (4 listed in DrugCentral).
• Indications: Dysuria and Urinary Tract Irritation.
• ATC code: G04BX06 (Other urologicals).
• Molecular formula: C11H11N5; molecular weight 213.24 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Dysuria
• Urinary Tract Irritation

Contraindications (54)

• Achalasia of esophagus
• Acute exacerbation of asthma
• Acute hepatitis
• Alcoholism
• Anemia
• Anemia due to enzyme deficiency
• Atony of colon
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Breastfeeding (mother)
• Chronic heart failure
• Chronic obstructive lung disease
• Conduction disorder of the heart
• Deficiency of glucose-6-phosphate dehydrogenase
• Depressive disorder
• Disease of blood AND/OR blood-forming organ
• Disease of liver
• Disorder of autonomic nervous system
• Disorder of coronary artery
• Fever greater than 100.4 Fahrenheit
• Folic acid deficiency
• Gastroesophageal reflux disease
• Glaucoma
• Glomerulonephritis
• Hepatic coma
• Hepatic encephalopathy
• Hepatic failure
• Hiatal hernia
• Hyperactive behavior
• Hyperammonemia
• + 24 more

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Replicase polyprotein 1ab	REP	unknown	Kd 5.30
Snake venom metalloproteinase Bap1	—	unknown	IC50 4.27
Sterile alpha and TIR motif-containing protein 1	SARM1	unknown	Ki 4.16
Sodium channel alpha subunit	SCN1A|SCN4A|SCN7A|SCN5A|SCN9A|SCN2A|SCN3A|SCN11A|SCN8A|SCN10A	blocker	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2001-06-26	FDA	—	ABLE

ATC classification

ATC code	Therapeutic hierarchy
G04BX06	GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Other urologicals

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Methaemoglobinaemia	354.6
Sulphaemoglobinaemia	278.9
Urinary tract infection	156.1
Anticholinergic syndrome	79.2
Dysuria	61.3
Nephrolithiasis	59.4
Cystitis	51.8
Drug hypersensitivity	48.6
Anaemia Heinz body	42.7
Haemolytic anaemia	37.8
Urinary retention	37.3
Emotional distress	30.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Phenazopyridine is on its molecule page.

• Molecular formula: C₁₁H₁₁N₅
• Molecular weight: 213.24 g/mol
• CAS number: 94-78-0
• InChIKey: QPFYXYFORQJZEC-FOCLMDBBSA-N
• PubChem CID: 4756

NC1=NC(N)=C(C=C1)\N=N\C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Phenazopyridine used for?

DrugCentral lists the following indications for Phenazopyridine: Dysuria and Urinary Tract Irritation.

How does Phenazopyridine work?

Its molecular targets in DrugCentral include REP, Snake venom metalloproteinase Bap1, SARM1 and SCN1A|SCN4A|SCN7A|SCN5A|SCN9A|SCN2A|SCN3A|SCN11A|SCN8A|SCN10A (blocker).

When was Phenazopyridine first approved?

Phenazopyridine was first approved by the FDA in 2001.

What is the chemical formula of Phenazopyridine?

Phenazopyridine has the molecular formula C11H11N5 and a molecular weight of 213.24 g/mol.

Sources

• DrugCentral drug card 2120 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201022 — compound record and bioactivity
• PubChem CID 4756 — chemical identifiers
• DrugBank DB01438 — drug record
• FDA UNII K2J09EMJ52 — substance identity
• DailyMed: FDA labels for Phenazopyridine — current prescribing information (label search)
• UniProt Q6SZW1 (SARM1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.