NAD(+) hydrolase SARM1 (SARM1)
Homo sapiens — UniProt Q6SZW1
Data last refreshed: (UniProt release unknown)
Key facts
NAD(+) hydrolase SARM1 (SARM1) is a protein from Homo sapiens identified by UniProt accession Q6SZW1, 724 residues long. MolForge cross-references it against 6 known binders and 182 disease associations.
- UniProt accession: Q6SZW1; gene symbol SARM1.
- Organism: Homo sapiens.
- Length: 724 amino acids.
- Top disease associations (Open Targets): hereditary folate malabsorption, genetic disorder and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NAD(+) hydrolase SARM1 |
|---|---|
| UniProt accession | Q6SZW1 |
| Gene | SARM1 |
| Organism | Homo sapiens |
| Length | 724 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (182)
Diseases linked to this target (Open Targets).
- hereditary folate malabsorption · score 0.51
- genetic disorder · score 0.39
- blood protein measurement · score 0.26
- low density lipoprotein cholesterol measurement · score 0.21
- heel bone mineral density · score 0.18
- grb2-related adapter protein 2 measurement · score 0.18
- apolipoprotein B measurement · score 0.17
- interleukin 5 measurement · score 0.17
- triglyceride measurement · score 0.17
- systolic blood pressure · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6SZW1-F1 | alphafold | PREDICTED | 85.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6SZW1.
Amino-acid sequence (724 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SARM1?
The strongest Open Targets associations for SARM1 are hereditary folate malabsorption, genetic disorder, blood protein measurement, low density lipoprotein cholesterol measurement and heel bone mineral density.
How long is the SARM1 protein?
The Homo sapiens SARM1 protein (UniProt Q6SZW1) is 724 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6SZW1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6SZW1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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