About Tyrosine-protein phosphatase non-receptor type 1
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) is a protein
from Homo sapiens identified by UniProt accession
P18031, 435 residues long.
MolForge cross-references it against 0 known binders and
397 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 1 |
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| UniProt accession | P18031 |
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| Gene | PTPN1 |
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| Organism | Homo sapiens |
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| Length | 435 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (14)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (397)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Alzheimer disease · score 0.46
- Parkinson disease · score 0.46
- multiple sclerosis · score 0.46
- lysosomal storage disease · score 0.46
- eosinophil count · score 0.42
- mean corpuscular volume · score 0.41
- hematocrit · score 0.41
- erythrocyte count · score 0.39
- hemoglobin measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P18031-F1 | alphafold | PREDICTED | 81.24 | — |
Amino-acid sequence (435 residues)
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK GSPLNAAPYG IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED HALSYWKPFL VNMCVATVLT AGAYLCYRFL FNSNT
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