Estramustine phosphate

Drug profile

Key facts

Estramustine phosphate is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1981. DrugCentral lists 5 molecular targets, including PTPN11, INPPL1 and PTPN6.

• Approval status: ofm (first approved 1981 by the FDA).
• Molecular targets: PTPN11, INPPL1, PTPN6 and PTPN1 (5 listed in DrugCentral).
• Molecular formula: C23H32Cl2NO6P; molecular weight 520.38 g/mol.

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Tyrosine-protein phosphatase non-receptor type 11	PTPN11	unknown	Kd 5.08
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	INPPL1	unknown	IC50 4.45
Protein-tyrosine phosphatase 1C	PTPN6	unknown	IC50 4.39
Tyrosine-protein phosphatase non-receptor type 1	PTPN1	unknown	IC50 4.20
Estrogen receptor beta	ESR2	modulator	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1981-12-24	FDA	—	PHARMACIA AND UPJOHN

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Osteonecrosis of jaw	94.6

Chemical structure

• Molecular formula: C₂₃H₃₂Cl₂NO₆P
• Molecular weight: 520.38 g/mol
• CAS number: 4891-15-0
• InChIKey: ADFOJJHRTBFFOF-RBRWEJTLSA-N
• PubChem CID: 259329

C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(OC(=O)N(CCCl)CCCl)=C4)[C@@H]1CC[C@@H]2OP(O)(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Estramustine phosphate work?

Its molecular targets in DrugCentral include PTPN11, INPPL1, PTPN6 and PTPN1.

When was Estramustine phosphate first approved?

Estramustine phosphate was first approved by the FDA in 1981.

What is the chemical formula of Estramustine phosphate?

Estramustine phosphate has the molecular formula C23H32Cl2NO6P and a molecular weight of 520.38 g/mol.

Sources

• DrugCentral drug card 1066 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200721 — compound record and bioactivity
• PubChem CID 259329 — chemical identifiers
• DrugBank DB14674 — drug record
• FDA UNII MUZ9585Y7B — substance identity
• DailyMed: FDA labels for Estramustine phosphate — current prescribing information (label search)
• UniProt Q06124 (PTPN11) — target protein
• UniProt O15357 (INPPL1) — target protein
• UniProt P29350 (PTPN6) — target protein
• UniProt P18031 (PTPN1) — target protein
• UniProt Q92731 (ESR2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

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