About Tyrosine-protein phosphatase non-receptor type 6
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) is a protein
from Homo sapiens identified by UniProt accession
P29350, 595 residues long.
MolForge cross-references it against 0 known binders and
507 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 6 |
|---|
| UniProt accession | P29350 |
|---|
| Gene | PTPN6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 595 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (507)
Diseases linked to this target (Open Targets).
- melanoma · score 0.33
- glioblastoma multiforme · score 0.30
- diffuse large B-cell lymphoma · score 0.29
- neuroinflammatory disorder · score 0.28
- platelet component distribution width · score 0.28
- endometrial cancer · score 0.26
- lung adenocarcinoma · score 0.26
- cutaneous melanoma · score 0.22
- head and neck squamous cell carcinoma · score 0.22
- retinal vasculature measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29350-F1 | alphafold | PREDICTED | 86.45 | — |
Amino-acid sequence (595 residues)
MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRVGDQVT HIRIQNSGDF YDLYGGEKFA TLTELVEYYT QQQGVLQDRD GTIIHLKYPL NCSDPTSERW YHGHMSGGQA ETLLQAKGEP WTFLVRESLS QPGDFVLSVL SDQPKAGPGS PLRVTHIKVM CEGGRYTVGG LETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KGKNRYKNIL PFDHSRVILQ GRDSNIPGSD YINANYIKNQ LLGPDENAKT YIASQGCLEA TVNDFWQMAW QENSRVIVMT TREVEKGRNK CVPYWPEVGM QRAYGPYSVT NCGEHDTTEY KLRTLQVSPL DNGDLIREIW HYQYLSWPDH GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ENISTKGLDC DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEVLQSQK GQESEYGNIT YPPAMKNAHA KASRTSSKHK EDVYENLHTK NKREEKVKKQ RSADKEKSKG SLKRK
Explore Tyrosine-protein phosphatase non-receptor type 6 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets