About Estrogen receptor beta
Estrogen receptor beta (ESR2) is a protein
from Homo sapiens identified by UniProt accession
Q92731, 530 residues long.
MolForge cross-references it against 0 known binders and
903 disease associations.
Target properties
| Protein name | Estrogen receptor beta |
|---|
| UniProt accession | Q92731 |
|---|
| Gene | ESR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 530 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (903)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.68
- breast cancer · score 0.63
- osteoporosis · score 0.60
- postmenopausal osteoporosis · score 0.59
- menopause · score 0.59
- breast carcinoma · score 0.57
- Atrophy · score 0.56
- schizoaffective disorder · score 0.56
- breast neoplasm · score 0.55
- neoplasm · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92731-F1 | alphafold | PREDICTED | 69.32 | — |
Amino-acid sequence (530 residues)
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHASN KGMEHLLNMK CKNVVPVYDL LLEMLNAHVL RGCKSSITGS ECSPAEDSKS KEGSQNPQSQ
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