Estetrol

Estrogen — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Estetrol is an ofp drug in the Estrogen class catalogued in DrugCentral. It was first approved by the FDA in 2021. Its mechanism of action is classified as Estrogen Receptor Agonists. DrugCentral lists 2 molecular targets, including ESR1 and ESR2. Recorded indications include Prevent pregnancy.

• Approval status: ofp (first approved 2021 by the FDA).
• Drug class: Estrogen.
• Mechanism of action: Estrogen Receptor Agonists.
• Molecular targets: ESR1 and ESR2 (2 listed in DrugCentral).
• Indications: Prevent pregnancy.
• ATC code: G03AA18 (Progestogens and estrogens, fixed combinations).
• Molecular formula: C18H24O4; molecular weight 304.39 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Prevent pregnancy

Contraindications (13)

• Acute hepatitis
• Adrenal insufficiency
• Atrial fibrillation
• Blood coagulation disorder
• Carcinoma of breast
• Cerebrovascular disease
• Coronary arteriosclerosis
• Diabetes mellitus
• Hepatocellular adenoma
• Hepatocellular carcinoma
• Hypertensive disorder
• Renal impairment
• Venous thromboembolic disease

Mechanism & targets

• Mechanism of action (MoA): Estrogen Receptor Agonists
• Established pharmacologic class: Estrogen

Molecular targets (2)

Target	Gene	Action	Activity
Estrogen receptor	ESR1	modulator	Ki 8.31
Estrogen receptor beta	ESR2	modulator	Ki 7.72

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2021-05-19	EMA	—	Gedeon Richter Plc; Estetra SPRL
2021-04-15	FDA	—	MAYNE PHARMA

ATC classification

ATC code	Therapeutic hierarchy
G03AA18	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
G03CA10	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › ESTROGENS › Natural and semisynthetic estrogens, plain

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Estetrol is on its molecule page.

• Molecular formula: C₁₈H₂₄O₄
• Molecular weight: 304.39 g/mol
• CAS number: 15183-37-6
• InChIKey: AJIPIJNNOJSSQC-NYLIRDPKSA-N
• PubChem CID: 27125

C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Estetrol used for?

DrugCentral lists the following indications for Estetrol: Prevent pregnancy.

How does Estetrol work?

Estetrol is classified as Estrogen Receptor Agonists; its molecular targets in DrugCentral include ESR1 (modulator) and ESR2 (modulator).

When was Estetrol first approved?

Estetrol was first approved by the FDA in 2021.

What drug class does Estetrol belong to?

Estetrol is in the Estrogen class.

What is the chemical formula of Estetrol?

Estetrol has the molecular formula C18H24O4 and a molecular weight of 304.39 g/mol.

Sources

• DrugCentral drug card 5450 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1230314 — compound record and bioactivity
• PubChem CID 27125 — chemical identifiers
• DrugBank DB12235 — drug record
• FDA UNII ENB39R14VF — substance identity
• DailyMed: FDA labels for Estetrol — current prescribing information (label search)
• UniProt P03372 (ESR1) — target protein
• UniProt Q92731 (ESR2) — target protein

How this page is built: methodology · editorial policy & corrections.