Etynodiol

Progestin — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Etynodiol is an ofp drug in the Progestin class catalogued in DrugCentral. It was first approved by the FDA in 1966. DrugCentral lists 5 molecular targets, including PGR, Ar and MAOA. Recorded indications include Contraception.

• Approval status: ofp (first approved 1966 by the FDA).
• Drug class: Progestin.
• Molecular targets: PGR, Ar, MAOA and ESR1 (5 listed in DrugCentral).
• Indications: Contraception.
• ATC code: G03AA01 (Progestogens and estrogens, fixed combinations).
• Molecular formula: C24H32O4; molecular weight 384.52 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Contraception

Off-label uses (1)

• Polycystic ovaries

Contraindications (39)

• Angina pectoris
• Benign mammary dysplasia
• Body fluid retention
• Carcinoma of female breast
• Cardiovascular event risk
• Cerebrovascular accident
• Cholestasis of pregnancy
• Deep venous thrombosis
• Depressive disorder
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Disorder of gallbladder
• Endometrial carcinoma
• Estrogen receptor positive tumor
• Heart valve disorder
• Hypercholesterolemia
• Hyperglycemia
• Hyperlipidemia
• Hypertensive disorder
• Hypertensive urgency
• Hypertriglyceridemia
• Intermenstrual bleeding - irregular
• Liver function tests abnormal
• Major Surgery with Prolonged Post-Operative Immobilization
• Malignant neoplasm of liver
• Malignant tumor of cervix
• Migraine
• Myocardial infarction
• Nonspecific Abnormal Papanicolaou Smear of Cervix
• + 9 more

Mechanism & targets

• Established pharmacologic class: Progestin

Molecular targets (5)

Target	Gene	Action	Activity
Progesterone receptor	PGR	unknown	Ki 7.68
Androgen receptor	Ar	unknown	Ki 5.68
Amine oxidase [flavin-containing] A	MAOA	unknown	IC50 5.37
Estrogen receptor	ESR1	unknown	—
Progesterone receptor	PGR	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1966-03-23	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
G03AA01	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
G03DC06	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS › Estren derivatives
G03FA06	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS AND ESTROGENS IN COMBINATION › Progestogens and estrogens, fixed combinations

Chemical structure

• Molecular formula: C₂₄H₃₂O₄
• Molecular weight: 384.52 g/mol
• CAS number: —
• InChIKey: ONKUMRGIYFNPJW-KIEAKMPYSA-N
• PubChem CID: 14687

CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(OC(C)=O)C#C)[C@@H]3CCC2=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Etynodiol used for?

DrugCentral lists the following indications for Etynodiol: Contraception.

How does Etynodiol work?

Its molecular targets in DrugCentral include PGR, Ar, MAOA and ESR1.

When was Etynodiol first approved?

Etynodiol was first approved by the FDA in 1966.

What drug class does Etynodiol belong to?

Etynodiol is in the Progestin class.

What is the chemical formula of Etynodiol?

Etynodiol has the molecular formula C24H32O4 and a molecular weight of 384.52 g/mol.

Sources

• DrugCentral drug card 1095 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200624 — compound record and bioactivity
• PubChem CID 14687 — chemical identifiers
• DrugBank DB00823 — drug record
• FDA UNII 9E01C36A9S — substance identity
• DailyMed: FDA labels for Etynodiol — current prescribing information (label search)
• UniProt P21397 (MAOA) — target protein
• UniProt P03372 (ESR1) — target protein
• UniProt P06401 (PGR) — target protein

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