Dienogest

Progestin — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Dienogest is an ofp drug in the Progestin class catalogued in DrugCentral. It was first approved by the FDA in 2010. DrugCentral lists 1 molecular target, including PGR. Recorded indications include Contraception and Dysmenorrhea.

• Approval status: ofp (first approved 2010 by the FDA).
• Drug class: Progestin.
• Molecular targets: PGR (1 listed in DrugCentral).
• Indications: Contraception and Dysmenorrhea.
• ATC code: G03AA16 (Progestogens and estrogens, fixed combinations).
• Molecular formula: C20H25NO2; molecular weight 311.43 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Contraception
• Dysmenorrhea

Off-label uses (1)

• Polycystic ovaries

Contraindications (54)

• Asthma
• Bed-ridden
• Body fluid retention
• Breast lump
• Carcinoma of female breast
• Cardiovascular event risk
• Cerebrovascular accident
• Chloasma
• Chorea
• Chronic heart failure
• Deep venous thrombosis
• Dementia
• Depressive disorder
• Diabetes mellitus
• Diplopia
• Disease of liver
• Disorder of coronary artery
• Disorder of gallbladder
• Endometrial carcinoma
• Endometriosis
• Epilepsy
• Estrogen receptor positive tumor
• Family history of malignant neoplasm of breast
• Functional visual loss
• Hepatic porphyria
• Humoral hypercalcemia of malignancy
• Hypercholesterolemia
• Hyperlipidemia
• Hyperlipoproteinemia
• Hypertensive disorder
• + 24 more

Mechanism & targets

• Established pharmacologic class: Progestin

Molecular targets (1)

Target	Gene	Action	Activity
Progesterone receptor	PGR	agonist	—

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2020-01-23	PMDA	—	Mochida Pharmaceutical Co., Ltd.
2010-05-06	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
G03AA16	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
G03AB08	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, sequential preparations
G03DB08	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS › Pregnadien derivatives
G03FA15	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS AND ESTROGENS IN COMBINATION › Progestogens and estrogens, fixed combinations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Uterine haemorrhage	54.2
Genital haemorrhage	42.2
Intermenstrual bleeding	41.3
Pharyngeal hypoaesthesia	34.6
Attention deficit hyperactivity disorder	33.1

Chemical structure

• Molecular formula: C₂₀H₂₅NO₂
• Molecular weight: 311.43 g/mol
• CAS number: —
• InChIKey: AZFLJNIPTRTECV-FUMNGEBKSA-N
• PubChem CID: 68861

C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)CC#N

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dienogest used for?

DrugCentral lists the following indications for Dienogest: Contraception and Dysmenorrhea.

How does Dienogest work?

Its molecular targets in DrugCentral include PGR (agonist).

When was Dienogest first approved?

Dienogest was first approved by the FDA in 2010.

What drug class does Dienogest belong to?

Dienogest is in the Progestin class.

What is the chemical formula of Dienogest?

Dienogest has the molecular formula C20H25NO2 and a molecular weight of 311.43 g/mol.

Sources

• DrugCentral drug card 871 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201864 — compound record and bioactivity
• PubChem CID 68861 — chemical identifiers
• DrugBank DB09123 — drug record
• FDA UNII 46M3EV8HHE — substance identity
• DailyMed: FDA labels for Dienogest — current prescribing information (label search)
• UniProt P06401 (PGR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.