Chlormadinone

GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Chlormadinone is a drug catalogued in DrugCentral. DrugCentral lists 5 molecular targets, including PGR, NR3C1 and Ar. Recorded indications include Endometriosis and Menorrhagia.

• Molecular targets: PGR, NR3C1, Ar and CYP2C19 (5 listed in DrugCentral).
• Indications: Endometriosis and Menorrhagia.
• ATC code: G03AA15 (Progestogens and estrogens, fixed combinations).
• Molecular formula: C23H29ClO4; molecular weight 404.93 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Endometriosis
• Menorrhagia

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Progesterone receptor	PGR	unknown	Ki 9.16
Glucocorticoid receptor	NR3C1	unknown	Ki 7.76
Androgen receptor	Ar	unknown	Ki 7.68
Cytochrome P450 2C19	CYP2C19	unknown	IC50 5.52
Sodium/potassium-transporting ATPase subunit alpha-2	ATP1A2	unknown	IC50 5.34

ATC classification

ATC code	Therapeutic hierarchy
G03AA15	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
G03AB07	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, sequential preparations
G03DB06	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS › Pregnadien derivatives
G03FB03	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS AND ESTROGENS IN COMBINATION › Progestogens and estrogens, sequential preparations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Meningioma	232.1
Ulnar tunnel syndrome	92.8
Menometrorrhagia	60.4
Intermenstrual bleeding	56.8
Diabetic metabolic decompensation	51.9
Scar	43.6
Avoidant personality disorder	43.3
Attention deficit hyperactivity disorder	39.6
XIth nerve injury	38.6
Claustrophobia	38.0
Exposure keratitis	37.9
Brain compression	37.8

Chemical structure

• Molecular formula: C₂₃H₂₉ClO₄
• Molecular weight: 404.93 g/mol
• CAS number: 302-22-7
• InChIKey: QMBJSIBWORFWQT-DFXBJWIESA-N
• PubChem CID: 5284533

CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Chlormadinone used for?

DrugCentral lists the following indications for Chlormadinone: Endometriosis and Menorrhagia.

How does Chlormadinone work?

Its molecular targets in DrugCentral include PGR, NR3C1, Ar and CYP2C19.

What is the chemical formula of Chlormadinone?

Chlormadinone has the molecular formula C23H29ClO4 and a molecular weight of 404.93 g/mol.

Sources

• DrugCentral drug card 600 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL110691 — compound record and bioactivity
• PubChem CID 5284533 — chemical identifiers
• DrugBank DB13528 — drug record
• FDA UNII SDS4N642GG — substance identity
• UniProt P04150 (NR3C1) — target protein
• UniProt P33261 (CYP2C19) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.