Desogestrel

Progestin — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Desogestrel is an ofp drug in the Progestin class catalogued in DrugCentral. It was first approved by the FDA in 1992. DrugCentral lists 2 molecular targets, including SHBG and PGR. Recorded indications include Contraception.

• Approval status: ofp (first approved 1992 by the FDA).
• Drug class: Progestin.
• Molecular targets: SHBG and PGR (2 listed in DrugCentral).
• Indications: Contraception.
• ATC code: G03AA09 (Progestogens and estrogens, fixed combinations).
• Molecular formula: C22H30O; molecular weight 310.48 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Contraception

Off-label uses (6)

• Abnormal uterine bleeding unrelated to menstrual cycle
• Amenorrhea
• Dysmenorrhea
• Female hypogonadism syndrome
• Menorrhagia
• Polycystic ovaries

Contraindications (58)

• Angina pectoris
• Asthma
• Benign mammary dysplasia
• Body fluid retention
• Breast lump
• Carcinoma of female breast
• Cardiovascular event risk
• Cerebrovascular accident
• Chloasma
• Cholestasis of pregnancy
• Chorea
• Deep venous thrombosis
• Dementia
• Depressive disorder
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Disorder of gallbladder
• Endometrial carcinoma
• Endometriosis
• Epilepsy
• Estrogen receptor positive tumor
• Family history of malignant neoplasm of breast
• Functional visual loss
• Heart valve disorder
• Hepatic porphyria
• Humoral hypercalcemia of malignancy
• Hypercholesterolemia
• Hyperglycemia
• Hyperlipidemia
• + 28 more

Mechanism & targets

• Established pharmacologic class: Progestin

Molecular targets (2)

Target	Gene	Action	Activity
Sex hormone-binding globulin	SHBG	unknown	Kd 6.60
Progesterone receptor	PGR	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1992-12-10	FDA	—	ORGANON USA INC

ATC classification

ATC code	Therapeutic hierarchy
G03AA09	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
G03AB05	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, sequential preparations
G03AC09	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens
G03FB10	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS AND ESTROGENS IN COMBINATION › Progestogens and estrogens, sequential preparations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Folliculitis	128.4
Pregnancy on oral contraceptive	120.9
Muscle injury	107.3
Irritable bowel syndrome	91.0
Lower respiratory tract infection	89.3
Gastrointestinal disorder	87.4
Death	78.4
Lip dry	77.0
Night sweats	76.7
Impaired healing	65.9
Gait inability	64.1
Duodenal ulcer perforation	63.7

Chemical structure

• Molecular formula: C₂₂H₃₀O
• Molecular weight: 310.48 g/mol
• CAS number: 54024-22-5
• InChIKey: RPLCPCMSCLEKRS-BPIQYHPVSA-N
• PubChem CID: 40973

CC[C@]12CC(=C)[C@H]3[C@@H](CCC4=CCCC[C@H]34)[C@@H]1CC[C@@]2(O)C#C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Desogestrel used for?

DrugCentral lists the following indications for Desogestrel: Contraception.

How does Desogestrel work?

Its molecular targets in DrugCentral include SHBG and PGR (agonist).

When was Desogestrel first approved?

Desogestrel was first approved by the FDA in 1992.

What drug class does Desogestrel belong to?

Desogestrel is in the Progestin class.

What is the chemical formula of Desogestrel?

Desogestrel has the molecular formula C22H30O and a molecular weight of 310.48 g/mol.

Sources

• DrugCentral drug card 818 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1533 — compound record and bioactivity
• PubChem CID 40973 — chemical identifiers
• DrugBank DB00304 — drug record
• FDA UNII 81K9V7M3A3 — substance identity
• DailyMed: FDA labels for Desogestrel — current prescribing information (label search)
• UniProt P04278 (SHBG) — target protein
• UniProt P06401 (PGR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.