Etonogestrel

Progestin — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Etonogestrel is an ofp drug in the Progestin class catalogued in DrugCentral. It was first approved by the FDA in 2001. DrugCentral lists 3 molecular targets, including SHBG, ESR1 and PGR. Recorded indications include Contraception.

• Approval status: ofp (first approved 2001 by the FDA).
• Drug class: Progestin.
• Molecular targets: SHBG, ESR1 and PGR (3 listed in DrugCentral).
• Indications: Contraception.
• ATC code: G03AC08 (Progestogens).
• Molecular formula: C22H28O2; molecular weight 324.46 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Contraception

Contraindications (50)

• Asthma
• Bed-ridden
• Benign Hepatic Cell Adenoma
• Body fluid retention
• Carcinoma of female breast
• Cerebrovascular accident
• Cerebrovascular disease
• Cholestasis of pregnancy
• Chronic heart failure
• Deep venous thrombosis
• Dementia
• Depressive disorder
• Diabetes mellitus
• Diabetes with Vascular Disease Complication
• Diplopia
• Disease of liver
• Disorder of coronary artery
• Disorder of gallbladder
• Endometrial carcinoma
• Estrogen receptor positive tumor
• Functional visual loss
• Heart valve disorder
• Hypercholesterolemia
• Hyperlipidemia
• Hypertensive disorder
• Hypertensive urgency
• Hypertriglyceridemia
• Intermenstrual bleeding - irregular
• Kidney disease
• Major Surgery with Prolonged Post-Operative Immobilization
• + 20 more

Mechanism & targets

• Established pharmacologic class: Progestin

Molecular targets (3)

Target	Gene	Action	Activity
Sex hormone-binding globulin	SHBG	unknown	Kd 8.23
Estrogen receptor	ESR1	unknown	—
Progesterone receptor	PGR	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2001-10-03	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
G03AC08	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
No adverse event	23546.6
Complication associated with device	21615.6
Device difficult to use	15057.3
Pregnancy with implant contraceptive	14851.9
Unintended pregnancy	14631.0
Device breakage	13708.5
Incorrect product administration duration	13562.4
Complication of device removal	13395.5
Product quality issue	12705.4
Device deployment issue	12223.1
Complication of device insertion	11157.0
Implant site pain	8827.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Etonogestrel is on its molecule page.

• Molecular formula: C₂₂H₂₈O₂
• Molecular weight: 324.46 g/mol
• CAS number: 54048-10-1
• InChIKey: GCKFUYQCUCGESZ-BPIQYHPVSA-N
• PubChem CID: 6917715

CC[C@]12CC(=C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@]2(O)C#C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Etonogestrel used for?

DrugCentral lists the following indications for Etonogestrel: Contraception.

How does Etonogestrel work?

Its molecular targets in DrugCentral include SHBG, ESR1 and PGR (agonist).

When was Etonogestrel first approved?

Etonogestrel was first approved by the FDA in 2001.

What drug class does Etonogestrel belong to?

Etonogestrel is in the Progestin class.

What is the chemical formula of Etonogestrel?

Etonogestrel has the molecular formula C22H28O2 and a molecular weight of 324.46 g/mol.

Sources

• DrugCentral drug card 1110 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1531 — compound record and bioactivity
• PubChem CID 6917715 — chemical identifiers
• DrugBank DB00294 — drug record
• FDA UNII 304GTH6RNH — substance identity
• DailyMed: FDA labels for Etonogestrel — current prescribing information (label search)
• UniProt P04278 (SHBG) — target protein
• UniProt P03372 (ESR1) — target protein
• UniProt P06401 (PGR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.