Sex hormone-binding globulin (SHBG)

About Sex hormone-binding globulin

Sex hormone-binding globulin (SHBG) is a protein from Homo sapiens identified by UniProt accession P04278, 402 residues long. MolForge cross-references it against 0 known binders and 527 disease associations.

Target properties

Protein name	Sex hormone-binding globulin
UniProt accession	P04278
Gene	SHBG
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (527)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.67
testosterone measurement · score 0.65
heel bone mineral density · score 0.50
body height · score 0.30
velocity of sound measurement · score 0.21
IGF-1 measurement · score 0.21
hip circumference · score 0.21
bone quantitative ultrasound measurement · score 0.20
estradiol measurement · score 0.17
triglyceride measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04278-F1	alphafold	PREDICTED	85.70	—

Amino-acid sequence (402 residues)

MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards