Nandrolone

Androgen — ALIMENTARY TRACT AND METABOLISM

Key facts

Nandrolone is an ofm drug in the Androgen class catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including Ar, PGR and SHBG. Recorded indications include Anemia of chronic renal failure.

• Approval status: ofm.
• Drug class: Androgen.
• Molecular targets: Ar, PGR, SHBG and SERPINA6 (6 listed in DrugCentral).
• Indications: Anemia of chronic renal failure.
• ATC code: A14AB01 (Estren derivatives).
• Molecular formula: C18H26O2; molecular weight 274.40 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Anemia of chronic renal failure

Off-label uses (2)

• Congenital hypoplastic anemia
• Hb SS disease

Contraindications (18)

• Benign prostatic hyperplasia
• Body fluid retention
• Breast Carcinoma in Males
• Breastfeeding (mother)
• Decompensated cardiac failure
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Heart disease
• Humoral hypercalcemia of malignancy
• Hypercalcemia
• Hypercholesterolemia
• Myocardial infarction
• Neoplasm of prostate
• Nephrotic syndrome
• Obstruction of bile duct
• Pregnancy, function
• Renal failure syndrome

Mechanism & targets

• Established pharmacologic class: Androgen

Molecular targets (6)

Target	Gene	Action	Activity
Androgen receptor	Ar	unknown	Ki 8.68
Progesterone receptor	PGR	unknown	Ki 7.65
Sex hormone-binding globulin	SHBG	unknown	Kd 6.30
Corticosteroid-binding globulin	SERPINA6	unknown	Ki 6.14
Solute carrier family 22 member 1	SLC22A1	unknown	IC50 4.45
Androgen receptor	AR	agonist	—

ATC classification

ATC code	Therapeutic hierarchy
A14AB01	ALIMENTARY TRACT AND METABOLISM › ANABOLIC AGENTS FOR SYSTEMIC USE › ANABOLIC STEROIDS › Estren derivatives
S01XA11	SENSORY ORGANS › OPHTHALMOLOGICALS › OTHER OPHTHALMOLOGICALS › Other ophthalmologicals

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug abuse	279.9

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Nandrolone is on its molecule page.

• Molecular formula: C₁₈H₂₆O₂
• Molecular weight: 274.40 g/mol
• CAS number: 434-22-0
• InChIKey: NPAGDVCDWIYMMC-IZPLOLCNSA-N
• PubChem CID: 9904

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@H]2O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Nandrolone used for?

DrugCentral lists the following indications for Nandrolone: Anemia of chronic renal failure.

How does Nandrolone work?

Its molecular targets in DrugCentral include Ar, PGR, SHBG and SERPINA6.

What drug class does Nandrolone belong to?

Nandrolone is in the Androgen class.

What is the chemical formula of Nandrolone?

Nandrolone has the molecular formula C18H26O2 and a molecular weight of 274.40 g/mol.

Sources

• DrugCentral drug card 1879 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2104906 — compound record and bioactivity
• PubChem CID 9904 — chemical identifiers
• DrugBank DB13169 — drug record
• FDA UNII 6PG9VR430D — substance identity
• UniProt P04278 (SHBG) — target protein
• UniProt P08185 (SERPINA6) — target protein
• UniProt O15245 (SLC22A1) — target protein
• UniProt P10275 (AR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.