Ethylestrenol

ALIMENTARY TRACT AND METABOLISM

Key facts

Ethylestrenol is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1964. DrugCentral lists 9 molecular targets, including Ar, PGR and SLC6A4.

• Approval status: ofm (first approved 1964 by the FDA).
• Molecular targets: Ar, PGR, SLC6A4 and CHRM2 (9 listed in DrugCentral).
• ATC code: A14AB02 (Estren derivatives).
• Molecular formula: C20H32O; molecular weight 288.48 g/mol.

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Androgen receptor	Ar	unknown	Ki 7.75
Progesterone receptor	PGR	unknown	Ki 7.58
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 7.37
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 6.98
Estrogen receptor	ESR1	unknown	Ki 6.50
Cytochrome P450 2C19	CYP2C19	unknown	IC50 5.89
Sodium-dependent noradrenaline transporter	SLC6A2	unknown	Ki 5.68
Acetylcholinesterase	ACHE	unknown	IC50 5.19
Androgen receptor	AR	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1964-05-28	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A14AB02	ALIMENTARY TRACT AND METABOLISM › ANABOLIC AGENTS FOR SYSTEMIC USE › ANABOLIC STEROIDS › Estren derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Ethylestrenol is on its molecule page.

• Molecular formula: C₂₀H₃₂O
• Molecular weight: 288.48 g/mol
• CAS number: 965-90-2
• InChIKey: AOXRBFRFYPMWLR-XGXHKTLJSA-N
• PubChem CID: 13765

CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@]12C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Ethylestrenol work?

Its molecular targets in DrugCentral include Ar, PGR, SLC6A4 and CHRM2.

When was Ethylestrenol first approved?

Ethylestrenol was first approved by the FDA in 1964.

What is the chemical formula of Ethylestrenol?

Ethylestrenol has the molecular formula C20H32O and a molecular weight of 288.48 g/mol.

Sources

• DrugCentral drug card 1094 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200623 — compound record and bioactivity
• PubChem CID 13765 — chemical identifiers
• DrugBank DB01493 — drug record
• FDA UNII ADC79EK5Q8 — substance identity
• DailyMed: FDA labels for Ethylestrenol — current prescribing information (label search)
• UniProt P31645 (SLC6A4) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt P03372 (ESR1) — target protein
• UniProt P33261 (CYP2C19) — target protein
• UniProt P23975 (SLC6A2) — target protein
• UniProt P22303 (ACHE) — target protein

How this page is built: methodology · editorial policy & corrections.