About Cytochrome P450 2C19
Cytochrome P450 2C19 (CYP2C19) is a protein
from Homo sapiens identified by UniProt accession
P33261, 490 residues long.
MolForge cross-references it against 0 known binders and
366 disease associations.
Target properties
| Protein name | Cytochrome P450 2C19 |
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| UniProt accession | P33261 |
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| Gene | CYP2C19 |
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| Organism | Homo sapiens |
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| Length | 490 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (366)
Diseases linked to this target (Open Targets).
- acute coronary syndrome · score 0.42
- response to clopidogrel · score 0.41
- bilirubin measurement · score 0.40
- lymphocyte count · score 0.34
- response to anticoagulant · score 0.33
- systolic blood pressure · score 0.33
- unipolar depression · score 0.32
- platelet reactivity measurement · score 0.32
- clopidogrel metabolite measurement · score 0.32
- serum metabolite measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P33261-F1 | alphafold | PREDICTED | 94.17 | — |
Amino-acid sequence (490 residues)
MDPFVVLVLC LSCLLLLSIW RQSSGRGKLP PGPTPLPVIG NILQIDIKDV SKSLTNLSKI YGPVFTLYFG LERMVVLHGY EVVKEALIDL GEEFSGRGHF PLAERANRGF GIVFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS IIFQKRFDYK DQQFLNLMEK LNENIRIVST PWIQICNNFP TIIDYFPGTH NKLLKNLAFM ESDILEKVKE HQESMDINNP RDFIDCFLIK MEKEKQNQQS EFTIENLVIT AADLLGAGTE TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRGHMPYTDA VVHEVQRYID LIPTSLPHAV TCDVKFRNYL IPKGTTILTS LTSVLHDNKE FPNPEMFDPR HFLDEGGNFK KSNYFMPFSA GKRICVGEGL ARMELFLFLT FILQNFNLKS LIDPKDLDTT PVVNGFASVP PFYQLCFIPV
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