Thioridazine

Phenothiazine — NERVOUS SYSTEM

Key facts

Thioridazine is an ofp drug in the Phenothiazine class catalogued in DrugCentral. It was first approved by the FDA in 1962. DrugCentral lists 61 molecular targets, including Chrm1|Chrm3|Chrm4|Chrm5|Chrm2, ADRA1D and ADRA1B. Recorded indications include Treatment-Resistant Schizophrenia.

• Approval status: ofp (first approved 1962 by the FDA).
• Drug class: Phenothiazine.
• Molecular targets: Chrm1|Chrm3|Chrm4|Chrm5|Chrm2, ADRA1D, ADRA1B and Adra1b (61 listed in DrugCentral).
• Indications: Treatment-Resistant Schizophrenia.
• ATC code: N05AC02 (Phenothiazines with piperidine structure).
• Molecular formula: C21H26N2S2; molecular weight 370.57 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Treatment-Resistant Schizophrenia

Contraindications (14)

• Breastfeeding (mother)
• Coma
• Congenital long QT syndrome
• Disease of blood AND/OR blood-forming organ
• Epilepsy
• Hyperkalemia
• Hypokalemia
• Neuroleptic malignant syndrome
• Orthostatic hypotension
• Predisposed to Torsades de Pointes Cardiac Arrhythmias
• Prolonged QT interval
• Senile dementia
• Stupor
• Tardive dyskinesia

Mechanism & targets

• Established pharmacologic class: Phenothiazine

Molecular targets (61)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor	Chrm1|Chrm3|Chrm4|Chrm5|Chrm2	unknown	IC50 8.70
Alpha-1D adrenergic receptor	ADRA1D	unknown	Ki 8.69
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 8.62
Alpha-1B adrenergic receptor	Adra1b	unknown	Ki 8.59
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 8.57
D(2) dopamine receptor	Drd2	unknown	IC50 8.55
Alpha-1A adrenergic receptor	Adra1a	unknown	IC50 8.29
5-hydroxytryptamine receptor 6	Htr6	antagonist	Ki 8.20
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 8.05
5-hydroxytryptamine receptor 2A	HTR2A	antagonist	EC50 8.00
D(4) dopamine receptor	DRD4	antagonist	Ki 7.98
Alpha-1A adrenergic receptor	ADRA1A	unknown	IC50 7.90
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 7.89
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 7.85
D(1A) dopamine receptor	Drd1	unknown	IC50 7.76
Serotonin 2 (5-HT2) receptor	Htr2c|Htr2a|Htr2b	unknown	IC50 7.74
Histamine H1 receptor	HRH1	antagonist	Ki 7.70
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 7.59
D(2) dopamine receptor	DRD2	antagonist	IC50 7.40
D(3) dopamine receptor	DRD3	antagonist	IC50 7.30

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1962-03-15	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
N05AC02	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Phenothiazines with piperidine structure

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: CYP2D6 · Actionable PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Antipsychotic drug level below therapeutic	857.3
Disinhibition	810.6
Therapeutic product effect variable	787.6
Obsessive-compulsive disorder	747.8
Euphoric mood	701.0
Akathisia	647.9
Increased appetite	625.9
Suicide attempt	393.7
Leukaemia	348.6
Leukopenia	305.2
Dyslipidaemia	291.3
Therapeutic product effect incomplete	266.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Thioridazine is on its molecule page.

• Molecular formula: C₂₁H₂₆N₂S₂
• Molecular weight: 370.57 g/mol
• CAS number: 50-52-2
• InChIKey: KLBQZWRITKRQQV-UHFFFAOYSA-N
• PubChem CID: 5452

CSC1=CC=C2SC3=CC=CC=C3N(CCC3CCCCN3C)C2=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Thioridazine used for?

DrugCentral lists the following indications for Thioridazine: Treatment-Resistant Schizophrenia.

How does Thioridazine work?

Its molecular targets in DrugCentral include Chrm1|Chrm3|Chrm4|Chrm5|Chrm2, ADRA1D, ADRA1B and Adra1b.

When was Thioridazine first approved?

Thioridazine was first approved by the FDA in 1962.

What drug class does Thioridazine belong to?

Thioridazine is in the Phenothiazine class.

What is the chemical formula of Thioridazine?

Thioridazine has the molecular formula C21H26N2S2 and a molecular weight of 370.57 g/mol.

Sources

• DrugCentral drug card 2637 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200916 — compound record and bioactivity
• PubChem CID 5452 — chemical identifiers
• DrugBank DB00679 — drug record
• FDA UNII N3D6TG58NI — substance identity
• DailyMed: FDA labels for Thioridazine — current prescribing information (label search)
• UniProt P25100 (ADRA1D) — target protein
• UniProt P35368 (ADRA1B) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P28223 (HTR2A) — target protein
• UniProt P21917 (DRD4) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.