Thiethylperazine

RESPIRATORY SYSTEM

Key facts

Thiethylperazine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1961. DrugCentral lists 17 molecular targets, including DRD2, ADRA1A and DRD3. Recorded indications include Nausea, Nausea and vomiting and Vomiting.

• Approval status: ofm (first approved 1961 by the FDA).
• Molecular targets: DRD2, ADRA1A, DRD3 and HRH1 (17 listed in DrugCentral).
• Indications: Nausea, Nausea and vomiting and Vomiting.
• ATC code: R06AD03 (Phenothiazine derivatives).
• Molecular formula: C22H29N3S2; molecular weight 399.62 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Nausea
• Nausea and vomiting
• Vomiting

Mechanism & targets

Molecular targets (17)

Target	Gene	Action	Activity
D(2) dopamine receptor	DRD2	antagonist	Ki 8.70
Alpha-1A adrenergic receptor	ADRA1A	unknown	Ki 8.70
D(3) dopamine receptor	DRD3	unknown	Ki 8.70
Histamine H1 receptor	HRH1	unknown	Ki 7.60
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 7.16
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 7.00
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 7.00
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 7.00
D(1A) dopamine receptor	DRD1	unknown	Ki 6.30
5-hydroxytryptamine receptor 1A	HTR1A	unknown	Ki 6.16
FAD-linked sulfhydryl oxidase ALR	GFER	unknown	AC50 5.96
Pleiotropic ABC efflux transporter of multiple drugs	PDR5	unknown	IC50 5.64
Muscarinic acetylcholine receptor M3	CHRM3	unknown	—
Muscarinic acetylcholine receptor M4	CHRM4	unknown	—
Muscarinic acetylcholine receptor M5	CHRM5	unknown	—
Muscarinic acetylcholine receptor M2	CHRM2	unknown	—
Muscarinic acetylcholine receptor M1	CHRM1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1961-07-18	FDA	—	NOVARTIS

ATC classification

ATC code	Therapeutic hierarchy
R06AD03	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Phenothiazine derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Thiethylperazine is on its molecule page.

• Molecular formula: C₂₂H₂₉N₃S₂
• Molecular weight: 399.62 g/mol
• CAS number: 1420-55-9
• InChIKey: XCTYLCDETUVOIP-UHFFFAOYSA-N
• PubChem CID: 5440

CCSC1=CC=C2SC3=CC=CC=C3N(CCCN3CCN(C)CC3)C2=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Thiethylperazine used for?

DrugCentral lists the following indications for Thiethylperazine: Nausea, Nausea and vomiting and Vomiting.

How does Thiethylperazine work?

Its molecular targets in DrugCentral include DRD2 (antagonist), ADRA1A, DRD3 and HRH1.

When was Thiethylperazine first approved?

Thiethylperazine was first approved by the FDA in 1961.

What is the chemical formula of Thiethylperazine?

Thiethylperazine has the molecular formula C22H29N3S2 and a molecular weight of 399.62 g/mol.

Sources

• DrugCentral drug card 2630 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1378 — compound record and bioactivity
• PubChem CID 5440 — chemical identifiers
• DrugBank DB00372 — drug record
• FDA UNII 8ETK1WAF6R — substance identity
• DailyMed: FDA labels for Thiethylperazine — current prescribing information (label search)
• UniProt P14416 (DRD2) — target protein
• UniProt P35348 (ADRA1A) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P35367 (HRH1) — target protein
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P28223 (HTR2A) — target protein

How this page is built: methodology · editorial policy & corrections.