FAD-linked sulfhydryl oxidase ALR (GFER)

About FAD-linked sulfhydryl oxidase ALR

FAD-linked sulfhydryl oxidase ALR (GFER) is a protein from Homo sapiens identified by UniProt accession P55789, 205 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	FAD-linked sulfhydryl oxidase ALR
UniProt accession	P55789
Gene	GFER
Organism	Homo sapiens
Length	205 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (11)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (138)

Diseases linked to this target (Open Targets).

Congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay · score 0.75
congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome · score 0.70
neurodegenerative disease · score 0.55
genetic disorder · score 0.47
mitochondrial disease · score 0.42
Intellectual disability · score 0.37
lysosomal storage disease · score 0.25
Red cell distribution width · score 0.18
hypertension · score 0.11
cardiovascular disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55789-F1	alphafold	PREDICTED	76.86	—

Amino-acid sequence (205 residues)

MAAPGERGRF HGGNLFFLPG GARSEMMDDL ATDARGRGAG RRDAAASAST PAQAPTSDSP VAEDASRRRP CRACVDFKTW MRTQQKRDTK FREDCPPDRE ELGRHSWAVL HTLAAYYPDL PTPEQQQDMA QFIHLFSKFY PCEECAEDLR KRLCRNHPDT RTRACFTQWL CHLHNEVNRK LGKPDFDCSK VDERWRDGWK DGSCD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards