Alimemazine

RESPIRATORY SYSTEM

Key facts

Alimemazine is an ofm drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including GFER and HRH1. Recorded indications include Allergic conjunctivitis, Allergic rhinitis, Angioedema and Dermatographic urticaria.

• Approval status: ofm.
• Molecular targets: GFER and HRH1 (2 listed in DrugCentral).
• Indications: Allergic conjunctivitis, Allergic rhinitis, Angioedema, Dermatographic urticaria and General anesthesia and others.
• ATC code: R06AD01 (Phenothiazine derivatives).
• Molecular formula: C18H22N2S; molecular weight 298.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (10)

• Allergic conjunctivitis
• Allergic rhinitis
• Angioedema
• Dermatographic urticaria
• General anesthesia
• Itching of skin
• Nasal congestion
• Nasal discharge
• Sneezing
• Urticaria

Contraindications (39)

• Acute disease of cardiovascular system
• Alcoholism
• Anemia
• Angina pectoris
• At risk for aspiration
• Benign prostatic hyperplasia
• Bradycardia
• Breastfeeding (mother)
• Carcinoma of female breast
• Chronic disease of respiratory system
• Chronic heart failure
• Coma
• Conduction disorder of the heart
• Congenital long QT syndrome
• Disease of liver
• Epilepsy
• Extrapyramidal disease
• Glaucoma
• Hyperglycemia
• Hyperprolactinemia
• Leukopenia
• Metabolic syndrome X
• Myocardial infarction
• Myocardial ischemia
• Neuroleptic malignant syndrome
• Neutropenic disorder
• Obesity
• Organophosphate poisoning
• Orthostatic hypotension
• Parkinsonism
• + 9 more

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
FAD-linked sulfhydryl oxidase ALR	GFER	unknown	AC50 5.90
Histamine H1 receptor	HRH1	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	ALLERGAN HERBERT

ATC classification

ATC code	Therapeutic hierarchy
R06AD01	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Phenothiazine derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Coma	1856.8
Intentional self-injury	1789.8
Intentional overdose	1751.0
Poisoning deliberate	1242.3
Somnolence	544.8
Toxicity to various agents	521.0
Drug abuse	422.4
Substance use disorder	352.2
Miosis	349.2
Drug use disorder	344.4
Suicide attempt	313.6
Tachycardia	293.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Alimemazine is on its molecule page.

• Molecular formula: C₁₈H₂₂N₂S
• Molecular weight: 298.45 g/mol
• CAS number: 84-96-8
• InChIKey: ZZHLYYDVIOPZBE-UHFFFAOYSA-N
• PubChem CID: 5574

CC(CN(C)C)CN1C2=CC=CC=C2SC2=C1C=CC=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Alimemazine used for?

DrugCentral lists the following indications for Alimemazine: Allergic conjunctivitis, Allergic rhinitis, Angioedema, Dermatographic urticaria, General anesthesia, Itching of skin, Nasal congestion and Nasal discharge and others.

How does Alimemazine work?

Its molecular targets in DrugCentral include GFER and HRH1 (antagonist).

What is the chemical formula of Alimemazine?

Alimemazine has the molecular formula C18H22N2S and a molecular weight of 298.45 g/mol.

Sources

• DrugCentral drug card 2749 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3989885 — compound record and bioactivity
• PubChem CID 5574 — chemical identifiers
• DrugBank DB01246 — drug record
• FDA UNII 362NW1LD6Z — substance identity
• DailyMed: FDA labels for Alimemazine — current prescribing information (label search)
• UniProt P55789 (GFER) — target protein
• UniProt P35367 (HRH1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

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