Mequitazine

RESPIRATORY SYSTEM

Key facts

Mequitazine is a drug catalogued in DrugCentral. DrugCentral lists 9 molecular targets, including CHRM3, CHRM1 and HRH1.

• Molecular targets: CHRM3, CHRM1, HRH1 and HRH1 (9 listed in DrugCentral).
• ATC code: R06AD07 (Phenothiazine derivatives).
• Molecular formula: C20H22N2S; molecular weight 322.47 g/mol.

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 8.28
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 8.25
Histamine H1 receptor	HRH1	unknown	Ki 8.24
Histamine H1 receptor	HRH1	unknown	Ki 8.00
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 7.96
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 7.96
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 7.85
Trypanothione reductase	TPR	unknown	IC50 4.66
Trypanothione reductase	—	unknown	IC50 4.27

ATC classification

ATC code	Therapeutic hierarchy
R06AD07	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Phenothiazine derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Tubulointerstitial nephritis and uveitis syndrome	46.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Mequitazine is on its molecule page.

• Molecular formula: C₂₀H₂₂N₂S
• Molecular weight: 322.47 g/mol
• CAS number: 29216-28-2
• InChIKey: HOKDBMAJZXIPGC-UHFFFAOYSA-N
• PubChem CID: 4066

C(C1CN2CCC1CC2)N1C2=CC=CC=C2SC2=CC=CC=C12

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Mequitazine work?

Its molecular targets in DrugCentral include CHRM3, CHRM1, HRH1 and HRH1.

What is the chemical formula of Mequitazine?

Mequitazine has the molecular formula C20H22N2S and a molecular weight of 322.47 g/mol.

Sources

• DrugCentral drug card 1707 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL73451 — compound record and bioactivity
• PubChem CID 4066 — chemical identifiers
• DrugBank DB01071 — drug record
• FDA UNII Y463242LY2 — substance identity
• UniProt P20309 (CHRM3) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P35367 (HRH1) — target protein
• UniProt P08912 (CHRM5) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P08172 (CHRM2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.