Cyamemazine

NERVOUS SYSTEM

Key facts

Cyamemazine is a drug catalogued in DrugCentral. DrugCentral lists 13 molecular targets, including HTR2A, DRD3 and DRD1.

• Molecular targets: HTR2A, DRD3, DRD1 and DRD2 (13 listed in DrugCentral).
• ATC code: N05AA06 (Phenothiazines with aliphatic side-chain).
• Molecular formula: C19H21N3S; molecular weight 323.46 g/mol.

Mechanism & targets

Molecular targets (13)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 2A	HTR2A	antagonist	Ki 8.80
D(3) dopamine receptor	DRD3	unknown	Ki 8.60
D(1A) dopamine receptor	DRD1	unknown	Ki 8.42
D(2) dopamine receptor	DRD2	unknown	Ki 8.24
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 7.92
5-hydroxytryptamine receptor 2C	HTR2C	antagonist	Ki 7.90
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 7.89
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 7.50
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 7.46
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 7.38
5-hydroxytryptamine receptor 7	HTR7	antagonist	Ki 7.20
5-hydroxytryptamine receptor 1A	HTR1A	antagonist	Ki 6.30
5-hydroxytryptamine receptor 3A	HTR3A	unknown	Ki 5.53

ATC classification

ATC code	Therapeutic hierarchy
N05AA06	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Phenothiazines with aliphatic side-chain

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Coma	3917.3
Poisoning deliberate	2441.1
Drug abuse	1298.8
Somnolence	896.4
Miosis	715.1
Toxicity to various agents	622.1
Altered state of consciousness	607.7
Drug use disorder	555.0
Asphyxia	442.4
Intentional overdose	412.3
Substance use disorder	410.3
Rhabdomyolysis	393.9

Chemical structure

• Molecular formula: C₁₉H₂₁N₃S
• Molecular weight: 323.46 g/mol
• CAS number: 3546-03-0
• InChIKey: SLFGIOIONGJGRT-UHFFFAOYSA-N
• PubChem CID: 62865

CC(CN(C)C)CN1C2=CC=CC=C2SC2=C1C=C(C=C2)C#N

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Cyamemazine work?

Its molecular targets in DrugCentral include HTR2A (antagonist), DRD3, DRD1 and DRD2.

What is the chemical formula of Cyamemazine?

Cyamemazine has the molecular formula C19H21N3S and a molecular weight of 323.46 g/mol.

Sources

• DrugCentral drug card 746 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2104153 — compound record and bioactivity
• PubChem CID 62865 — chemical identifiers
• DrugBank DB09000 — drug record
• FDA UNII A2JGV5CNU4 — substance identity
• UniProt P28223 (HTR2A) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P21728 (DRD1) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P28335 (HTR2C) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.